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- W2892419488 abstract "Abstract Bioactive glasses (BGs) as promising biomaterials have been widely used for bone tissue regeneration and replacement because of their excellent biocompatibility, biodegradability, and osteoconductivity. In the past decade, mesoporous bioactive glasses (MBG) with an ordered mesoporous structure and great specific surface area have been developed for in situ bone therapy and regenerative application. This paper reviews the preparation mechanism of MGB particles, coatings, fibers, and scaffolds and discusses the effects of chemical components, structure-directing agents, and reaction condition on the mesoporous structure. Implant-associated infections and poor bone-forming activity still occur in bone defects, which are overcome by loading antibiotic drugs or osteogenic drugs/growth factors on MBG carriers. MBGs as drug delivery systems have the following advantages: (i) the ordered mesopores in MBGs as drug channels increase the loading amount of drugs/growth factors; and (ii) the functional groups within MBGs enhance the controlled release property due to the hydrogen-bonding interaction. The future perspectives of MBGs loaded with drugs/growth factors are discussed for in vivo bone regeneration application to treat implant-associated infects and enhance osteogenesis." @default.
- W2892419488 created "2018-10-05" @default.
- W2892419488 creator A5006840130 @default.
- W2892419488 creator A5019155889 @default.
- W2892419488 creator A5078571357 @default.
- W2892419488 date "2019-01-01" @default.
- W2892419488 modified "2023-10-15" @default.
- W2892419488 title "Mesoporous Bioactive Glasses: Fabrication, Structure, Drug Delivery Property, and Therapeutic Potential" @default.
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- W2892419488 doi "https://doi.org/10.1016/b978-0-08-102196-5.00004-5" @default.
- W2892419488 hasPublicationYear "2019" @default.
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