Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892426232> ?p ?o ?g. }
- W2892426232 abstract "Abstract Membrane-active, basic amphipathic peptides represent a class of biomolecules with diverse functions. Sequentially close protein segments also show similar behaviour in several ways. Here we investigated the effect of the lipid mediator lysophosphatidic acid (LPA) on the conformation of structurally disordered peptides including extracellular antimicrobial peptides (AMPs), and calmodulin-binding motifs derived from cytosolic and membrane target proteins. The interaction with associated LPA resulted in gain of ordered secondary structure elements, which for most cases were previously uncharacteristic of the particular peptide. Results revealed mechanism of the LPA-peptide interactions with regulation of the lipid on peptide conformation and oligomerization in a concentration-dependent manner involving (1) relocation of tryptophan residues into the lipid cluster, (2) multiple contacts between the binding partners dictated by complex driving forces, (3) multiple peptide binding to LPA associates with an affinity in the low micromolar range, and (4) selectivity for LPA compared with structurally related lipids. In line with recent findings showing endogenous molecules inducing structural changes in AMPs, we propose that accumulation of LPA in signalling or pathological processes might modulate host-defense activity or trigger certain processes by direct interaction with cationic amphipathic peptide sequences." @default.
- W2892426232 created "2018-10-05" @default.
- W2892426232 creator A5000579108 @default.
- W2892426232 creator A5013086121 @default.
- W2892426232 creator A5023886494 @default.
- W2892426232 creator A5031302031 @default.
- W2892426232 creator A5046022969 @default.
- W2892426232 creator A5085632764 @default.
- W2892426232 date "2018-09-28" @default.
- W2892426232 modified "2023-10-14" @default.
- W2892426232 title "The lipid mediator lysophosphatidic acid induces folding of disordered peptides with basic amphipathic character into rare conformations" @default.
- W2892426232 cites W1493349125 @default.
- W2892426232 cites W1496223818 @default.
- W2892426232 cites W1523503670 @default.
- W2892426232 cites W1542159434 @default.
- W2892426232 cites W1548587858 @default.
- W2892426232 cites W1588979652 @default.
- W2892426232 cites W1806089348 @default.
- W2892426232 cites W1965676885 @default.
- W2892426232 cites W1973609947 @default.
- W2892426232 cites W1975356564 @default.
- W2892426232 cites W1977643725 @default.
- W2892426232 cites W1977802438 @default.
- W2892426232 cites W1983065854 @default.
- W2892426232 cites W1992045220 @default.
- W2892426232 cites W1993050100 @default.
- W2892426232 cites W1994446262 @default.
- W2892426232 cites W2001280469 @default.
- W2892426232 cites W2002721539 @default.
- W2892426232 cites W2004044991 @default.
- W2892426232 cites W2006192061 @default.
- W2892426232 cites W2007744639 @default.
- W2892426232 cites W2017740377 @default.
- W2892426232 cites W2019123717 @default.
- W2892426232 cites W2024821551 @default.
- W2892426232 cites W2025187028 @default.
- W2892426232 cites W2028038006 @default.
- W2892426232 cites W2031811477 @default.
- W2892426232 cites W2033950000 @default.
- W2892426232 cites W2034107677 @default.
- W2892426232 cites W2040566502 @default.
- W2892426232 cites W2040826376 @default.
- W2892426232 cites W2043935934 @default.
- W2892426232 cites W2047706128 @default.
- W2892426232 cites W2050996524 @default.
- W2892426232 cites W2052366943 @default.
- W2892426232 cites W2052795682 @default.
- W2892426232 cites W2065568411 @default.
- W2892426232 cites W2066846031 @default.
- W2892426232 cites W2068434373 @default.
- W2892426232 cites W2083963151 @default.
- W2892426232 cites W2084845164 @default.
- W2892426232 cites W2091466360 @default.
- W2892426232 cites W2108812575 @default.
- W2892426232 cites W2120385383 @default.
- W2892426232 cites W2123606696 @default.
- W2892426232 cites W2146543014 @default.
- W2892426232 cites W2403862021 @default.
- W2892426232 cites W2412145118 @default.
- W2892426232 cites W2418420427 @default.
- W2892426232 cites W2576285511 @default.
- W2892426232 cites W2596167430 @default.
- W2892426232 cites W2767894630 @default.
- W2892426232 cites W2793696734 @default.
- W2892426232 cites W2474656707 @default.
- W2892426232 doi "https://doi.org/10.1038/s41598-018-32786-4" @default.
- W2892426232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6162328" @default.
- W2892426232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30266943" @default.
- W2892426232 hasPublicationYear "2018" @default.
- W2892426232 type Work @default.
- W2892426232 sameAs 2892426232 @default.
- W2892426232 citedByCount "10" @default.
- W2892426232 countsByYear W28924262322019 @default.
- W2892426232 countsByYear W28924262322020 @default.
- W2892426232 countsByYear W28924262322021 @default.
- W2892426232 countsByYear W28924262322023 @default.
- W2892426232 crossrefType "journal-article" @default.
- W2892426232 hasAuthorship W2892426232A5000579108 @default.
- W2892426232 hasAuthorship W2892426232A5013086121 @default.
- W2892426232 hasAuthorship W2892426232A5023886494 @default.
- W2892426232 hasAuthorship W2892426232A5031302031 @default.
- W2892426232 hasAuthorship W2892426232A5046022969 @default.
- W2892426232 hasAuthorship W2892426232A5085632764 @default.
- W2892426232 hasBestOaLocation W28924262321 @default.
- W2892426232 hasConcept C104317684 @default.
- W2892426232 hasConcept C12554922 @default.
- W2892426232 hasConcept C15920480 @default.
- W2892426232 hasConcept C167625842 @default.
- W2892426232 hasConcept C170493617 @default.
- W2892426232 hasConcept C178790620 @default.
- W2892426232 hasConcept C185592680 @default.
- W2892426232 hasConcept C2107291 @default.
- W2892426232 hasConcept C2776661833 @default.
- W2892426232 hasConcept C2779281246 @default.
- W2892426232 hasConcept C39944091 @default.
- W2892426232 hasConcept C41625074 @default.
- W2892426232 hasConcept C51639874 @default.
- W2892426232 hasConcept C521977710 @default.
- W2892426232 hasConcept C55493867 @default.
- W2892426232 hasConcept C67407626 @default.