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- W2892430055 abstract "Abstract Polycystic ovary syndrome is the most common endocrine disorder affecting women during their reproductive age. Despite the range of clinical presentations and diagnostic criteria, PCOS appears to be a highly heritable condition with genetic factors accounting for ~ 70%–80% of the variation in susceptibility to the condition. As a polygenic disorder involving a range of endocrine and metabolic pathways, it has been difficult to isolate genetic variants using the candidate gene approach. Genome-wide analytical techniques such as genome-wide association studies have identified numerous loci of interest. Promising variants in the genes encoding FSH, LH, and the FSH receptor suggest a neuroendocrine origin of the condition, and variants in the insulin receptor gene confirm the ongoing association with insulin resistance. However, the majority of the variance in heritability remains unexplained, and it is likely that further studies using whole exome or whole genome sequencing will identify novel causative genetic variants." @default.
- W2892430055 created "2018-10-05" @default.
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- W2892430055 date "2019-01-01" @default.
- W2892430055 modified "2023-09-23" @default.
- W2892430055 title "Genetics of Polycystic Ovary Syndrome" @default.
- W2892430055 doi "https://doi.org/10.1016/b978-0-12-813570-9.00020-6" @default.
- W2892430055 hasPublicationYear "2019" @default.
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