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- W2892430861 abstract "Sodium fluoride is one of the neglected environmental contaminants. Inorganic fluorides in the environment are found in the air, water, and land. In the study, forty-male Wistar albino rats were randomly divided into four groups with 10 rats in a group. Group A was the control group which was given normal saline, Group B was exposed to 300 ppm of NaF in drinking water, while Groups C and D received NaF along Rutin (100 mg/kg and 200 mg/kg) orally daily for a week. Administration of NaF alone led to significant increases in blood pressure, and deceased serum nitric oxide. Immunohistochemistry revealed higher expressions of kidney injury molecule I (Kim-1), nuclear factor kappa beta (NF-κB), and down regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) in rats administered NaF. Rutin co-treatment with NaF normalized blood pressure, lowered Kim-1 and NF-κB expressions, and improved nitric oxide bioavailability." @default.
- W2892430861 created "2018-10-05" @default.
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- W2892430861 date "2018-09-26" @default.
- W2892430861 modified "2023-09-29" @default.
- W2892430861 title "Ameliorative effect of Rutin on sodium fluoride-induced hypertension through modulation of Kim-1/NF-κB/Nrf2 signaling pathway in rats" @default.
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- W2892430861 doi "https://doi.org/10.1002/tox.22636" @default.
- W2892430861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30259632" @default.
- W2892430861 hasPublicationYear "2018" @default.
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