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• W2892432318 abstract "Abstract Hepatocellular carcinoma ( HCC ) is one of the most common and deadly malignant tumors in the world, especially in China. Follistatin‐like protein 5 ( FSTL 5) is a member of the FSTL family, which is involved in cell proliferation, migration, differentiation, and embryo development. We aimed to investigate the function and underlying mechanism of FSTL 5 in HCC . FSTL 5 expression was determined by immunohistochemistry staining in a liver cancer tissue microarray ( TMA ) and the correlation between FSTL 5 and the prognosis of HCC patients was analysed. Further proliferation assay, colony formation assay, flow cytometry, and xenograft tumor model were performed to investigate the bioeffects of FSTL 5 in HCC in vitro and in vivo. We found that FSTL 5 expression was downregulated in HCC tissues and positively correlated with the prognosis of patients with HCC at tumor node metastasis stage I/II. Overexpression of FSTL 5 efficiently impaired HCC growth both in vivo and in vitro with an exogenous manner. Mechanistic investigation demonstrated that FSTL 5 promoted HCC cell apoptosis in a caspase‐dependent manner and regulated Bcl‐2 family proteins. These results indicate that FSTL 5 may be a potential novel target for HCC treatment, and a biomarker for tumor prognosis." @default.
• W2892432318 created "2018-10-05" @default.
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• W2892432318 date "2018-09-25" @default.
• W2892432318 modified "2023-10-01" @default.
• W2892432318 title "Follistatin-like protein 5 inhibits hepatocellular carcinoma progression by inducing caspase-dependent apoptosis and regulating Bcl-2 family proteins" @default.
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• W2892432318 doi "https://doi.org/10.1111/jcmm.13906" @default.
• W2892432318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6237577" @default.
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• W2892432318 hasPublicationYear "2018" @default.
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