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- W2892433350 abstract "SUMMARY Toxic proteins are prime targets for molecular farming and efficient tools for targeted cell ablation in genetics, developmental biology, and biotechnology. Achieving conditional activity of cytotoxins and their maintenance in form of stably transformed transgenes is challenging. We demonstrate here a switchable version of the highly cytotoxic bacterial ribonuclease barnase by using efficient temperature-dependent control of protein accumulation in living multicellular organisms. By tuning the levels of the protein, we were able to control the fate of a plant organ in vivo . The on-demand-formation of specialized epidermal cells (trichomes) through manipulating stabilization versus destabilization of barnase is a proof-of-concept for a robust and powerful tool for conditional switchable cell arrest. We present this tool both as a potential novel strategy for the manufacture and accumulation of cytotoxic proteins and toxic high-value products in plants or for conditional genetic cell ablation." @default.
- W2892433350 created "2018-10-05" @default.
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- W2892433350 date "2018-09-29" @default.
- W2892433350 modified "2023-09-23" @default.
- W2892433350 title "Switching toxic protein function in life cells" @default.
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- W2892433350 doi "https://doi.org/10.1101/430439" @default.
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