FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892435346> ?p ?o ?g. }

• W2892435346 abstract "Afterload reduction is a cornerstone in the management of patients with heart failure (HF) and reduced ejection fraction. However, arterial load and the effect of HF therapies on afterload might vary between individuals. Tailoring vasoactive medicines to patients with HF based upon better understanding of arterial afterload may enable better individualization of therapy.Subjects with HF and reduced ejection fraction underwent aggressive titration of vasoactive HF therapies with assessment of central aortic waveforms analyzed using pulse wave, wave separation, and arterial reservoir models. Clinical response to treatment was assessed using the 6-minute walk test distance, which increased in 25 subjects and decreased or remained unchanged in 13. Subjects with improvement on therapy displayed higher aortic pressure wave pulsatility (central pulse pressure [PP], reflected pressure wave, and reservoir pressure) at study entry compared with subjects without improvement (all P<0.05). Parameters derived by the arterial analysis methods were strongly correlated with one another and displayed similar ability to predict improvement. Aortic pressure pulsatility significantly decreased in subjects with functional improvement, whereas no change was observed in patients without functional improvement (P for interaction <0.05). These differences in arterial load at baseline and on therapy were not apparent from conventional brachial artery cuff pressure assessments.Increased aortic pressure wave pulsatility and greater decrease in pulsatility on treatment are associated with functional improvement in patients with HF and reduced ejection fraction receiving aggressive vasodilator titration. These differences are not identifiable using brachial cuff pressures. Central aortic waveform analysis may enable better individualization of vasoactive therapies in chronic HF and reduced ejection fraction.URL: http://www.clinicaltrials.gov. Unique identifier: NCT00588692." @default.
• W2892435346 created "2018-10-05" @default.
• W2892435346 creator A5011309968 @default.
• W2892435346 creator A5028644714 @default.
• W2892435346 creator A5030461468 @default.
• W2892435346 creator A5056266017 @default.
• W2892435346 creator A5061114305 @default.
• W2892435346 creator A5069131955 @default.
• W2892435346 creator A5078998559 @default.
• W2892435346 creator A5089220231 @default.
• W2892435346 creator A5090927098 @default.
• W2892435346 date "2017-02-01" @default.
• W2892435346 modified "2023-10-07" @default.
• W2892435346 title "Aortic Waveform Analysis to Individualize Treatment in Heart Failure" @default.
• W2892435346 cites W1979056880 @default.
• W2892435346 cites W1998710298 @default.
• W2892435346 cites W2025012812 @default.
• W2892435346 cites W2026329497 @default.
• W2892435346 cites W2032455684 @default.
• W2892435346 cites W2065445964 @default.
• W2892435346 cites W2072934196 @default.
• W2892435346 cites W2074594580 @default.
• W2892435346 cites W2079342459 @default.
• W2892435346 cites W2090657329 @default.
• W2892435346 cites W2091890699 @default.
• W2892435346 cites W2104058362 @default.
• W2892435346 cites W2108211140 @default.
• W2892435346 cites W2112943642 @default.
• W2892435346 cites W2119340816 @default.
• W2892435346 cites W2141731247 @default.
• W2892435346 cites W2163243062 @default.
• W2892435346 cites W2168072390 @default.
• W2892435346 cites W2169120089 @default.
• W2892435346 cites W2169122107 @default.
• W2892435346 cites W2178738676 @default.
• W2892435346 cites W2201012012 @default.
• W2892435346 cites W2324279094 @default.
• W2892435346 cites W4211082352 @default.
• W2892435346 doi "https://doi.org/10.1161/circheartfailure.116.003516" @default.
• W2892435346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5308883" @default.
• W2892435346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28159826" @default.
• W2892435346 hasPublicationYear "2017" @default.
• W2892435346 type Work @default.
• W2892435346 sameAs 2892435346 @default.
• W2892435346 citedByCount "19" @default.
• W2892435346 countsByYear W28924353462017 @default.
• W2892435346 countsByYear W28924353462018 @default.
• W2892435346 countsByYear W28924353462019 @default.
• W2892435346 countsByYear W28924353462020 @default.
• W2892435346 countsByYear W28924353462021 @default.
• W2892435346 countsByYear W28924353462022 @default.
• W2892435346 countsByYear W28924353462023 @default.
• W2892435346 crossrefType "journal-article" @default.
• W2892435346 hasAuthorship W2892435346A5011309968 @default.
• W2892435346 hasAuthorship W2892435346A5028644714 @default.
• W2892435346 hasAuthorship W2892435346A5030461468 @default.
• W2892435346 hasAuthorship W2892435346A5056266017 @default.
• W2892435346 hasAuthorship W2892435346A5061114305 @default.
• W2892435346 hasAuthorship W2892435346A5069131955 @default.
• W2892435346 hasAuthorship W2892435346A5078998559 @default.
• W2892435346 hasAuthorship W2892435346A5089220231 @default.
• W2892435346 hasAuthorship W2892435346A5090927098 @default.
• W2892435346 hasBestOaLocation W28924353461 @default.
• W2892435346 hasConcept C123576724 @default.
• W2892435346 hasConcept C126322002 @default.
• W2892435346 hasConcept C164705383 @default.
• W2892435346 hasConcept C17140001 @default.
• W2892435346 hasConcept C2775850156 @default.
• W2892435346 hasConcept C2776452961 @default.
• W2892435346 hasConcept C2777953023 @default.
• W2892435346 hasConcept C2778198053 @default.
• W2892435346 hasConcept C2778319312 @default.
• W2892435346 hasConcept C39124391 @default.
• W2892435346 hasConcept C71924100 @default.
• W2892435346 hasConcept C78085059 @default.
• W2892435346 hasConcept C84393581 @default.
• W2892435346 hasConceptScore W2892435346C123576724 @default.
• W2892435346 hasConceptScore W2892435346C126322002 @default.
• W2892435346 hasConceptScore W2892435346C164705383 @default.
• W2892435346 hasConceptScore W2892435346C17140001 @default.
• W2892435346 hasConceptScore W2892435346C2775850156 @default.
• W2892435346 hasConceptScore W2892435346C2776452961 @default.
• W2892435346 hasConceptScore W2892435346C2777953023 @default.
• W2892435346 hasConceptScore W2892435346C2778198053 @default.
• W2892435346 hasConceptScore W2892435346C2778319312 @default.
• W2892435346 hasConceptScore W2892435346C39124391 @default.
• W2892435346 hasConceptScore W2892435346C71924100 @default.
• W2892435346 hasConceptScore W2892435346C78085059 @default.
• W2892435346 hasConceptScore W2892435346C84393581 @default.
• W2892435346 hasIssue "2" @default.
• W2892435346 hasLocation W28924353461 @default.
• W2892435346 hasLocation W28924353462 @default.
• W2892435346 hasLocation W28924353463 @default.
• W2892435346 hasLocation W28924353464 @default.
• W2892435346 hasOpenAccess W2892435346 @default.
• W2892435346 hasPrimaryLocation W28924353461 @default.
• W2892435346 hasRelatedWork W1853919072 @default.
• W2892435346 hasRelatedWork W2071823802 @default.
• W2892435346 hasRelatedWork W2097766117 @default.
• W2892435346 hasRelatedWork W2151600317 @default.

• next