FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892438659> ?p ?o ?g. }

• W2892438659 endingPage "5089" @default.
• W2892438659 startingPage "5077" @default.
• W2892438659 abstract "Background: Amino acids are the basic structural units of proteins as well as the precursors of many compounds with biological activity. The addition of boron reportedly induces changes in the chemical-biological profile of amino acids. Methods: We compiled information on the biological effect of some compounds and discussed the structure-activity relationship of the addition of boron. The specific focus presently is on borinic derivatives of α-amino acids, the specific changes in biological activity caused by the addition of a boron-containing moiety, and the identification of some attractive compounds for testing as potential new drugs. Results: Borinic derivatives of α-amino acids have been widely synthesized and tested as potential new therapeutic tools. The B-N (1.65 A°) or B-C (1.61 A°) or B-O (1.50 A°) bond is often key for the stability at different pHs and temperatures and activity of these compounds. The chemical features of synthesized derivatives, such as the specific moieties and the logP, polarizability and position of the boron atom are clearly linked to their pharmacodynamic and pharmacokinetic profiles. Some mechanisms of action have been suggested or demonstrated, while those responsible for other effects remain unknown. Conclusion: The increasing number of synthetic borinic derivatives of α-amino acids as well as the recently reported crystal structures are providing new insights into the stability of these compounds at different pHs and temperatures, their interactions on drug targets, and the ring formation of five-membered heterocycles. Further research is required to clarify the ways to achieve specific synthesis, the mechanisms involved in the observed biological effect, and the toxicological profile of this type of boron-containing compounds (BCCs)." @default.
• W2892438659 created "2018-10-05" @default.
• W2892438659 creator A5050806913 @default.
• W2892438659 creator A5056524327 @default.
• W2892438659 creator A5058723236 @default.
• W2892438659 creator A5074014733 @default.
• W2892438659 date "2019-10-22" @default.
• W2892438659 modified "2023-09-23" @default.
• W2892438659 title "Structural and Biological Overview of Boron-containing Amino Acids in the Medicinal Chemistry Field" @default.
• W2892438659 cites W1004718755 @default.
• W2892438659 cites W1163613478 @default.
• W2892438659 cites W1711613787 @default.
• W2892438659 cites W1816716723 @default.
• W2892438659 cites W1860356880 @default.
• W2892438659 cites W1978799293 @default.
• W2892438659 cites W1979417745 @default.
• W2892438659 cites W1983346392 @default.
• W2892438659 cites W1999214982 @default.
• W2892438659 cites W2001518334 @default.
• W2892438659 cites W2002106501 @default.
• W2892438659 cites W2002672521 @default.
• W2892438659 cites W2011779178 @default.
• W2892438659 cites W2016386037 @default.
• W2892438659 cites W2018370154 @default.
• W2892438659 cites W2019905159 @default.
• W2892438659 cites W2022611345 @default.
• W2892438659 cites W2026295412 @default.
• W2892438659 cites W2037528387 @default.
• W2892438659 cites W2045961305 @default.
• W2892438659 cites W2052470179 @default.
• W2892438659 cites W2052717696 @default.
• W2892438659 cites W2060856288 @default.
• W2892438659 cites W2062361113 @default.
• W2892438659 cites W2065041221 @default.
• W2892438659 cites W2065820783 @default.
• W2892438659 cites W2067381456 @default.
• W2892438659 cites W2068339421 @default.
• W2892438659 cites W2069946470 @default.
• W2892438659 cites W2072131284 @default.
• W2892438659 cites W2072693049 @default.
• W2892438659 cites W2082552668 @default.
• W2892438659 cites W2082891466 @default.
• W2892438659 cites W2089391882 @default.
• W2892438659 cites W2091125532 @default.
• W2892438659 cites W2091882194 @default.
• W2892438659 cites W2101760457 @default.
• W2892438659 cites W2104255578 @default.
• W2892438659 cites W2113451125 @default.
• W2892438659 cites W2120692119 @default.
• W2892438659 cites W2120957361 @default.
• W2892438659 cites W2124671697 @default.
• W2892438659 cites W2130421514 @default.
• W2892438659 cites W2145435092 @default.
• W2892438659 cites W2148223602 @default.
• W2892438659 cites W2150152738 @default.
• W2892438659 cites W2155346762 @default.
• W2892438659 cites W2155393139 @default.
• W2892438659 cites W2170177806 @default.
• W2892438659 cites W2217312475 @default.
• W2892438659 cites W2230848956 @default.
• W2892438659 cites W2294730858 @default.
• W2892438659 cites W2311753455 @default.
• W2892438659 cites W2312895420 @default.
• W2892438659 cites W2324297243 @default.
• W2892438659 cites W2332053416 @default.
• W2892438659 cites W2338384895 @default.
• W2892438659 cites W2346391667 @default.
• W2892438659 cites W2466876797 @default.
• W2892438659 cites W2469894527 @default.
• W2892438659 cites W2478024965 @default.
• W2892438659 cites W2486481109 @default.
• W2892438659 cites W2509295998 @default.
• W2892438659 cites W2515850068 @default.
• W2892438659 cites W2517453414 @default.
• W2892438659 cites W2567564453 @default.
• W2892438659 cites W2574409010 @default.
• W2892438659 cites W2598467402 @default.
• W2892438659 cites W2610008526 @default.
• W2892438659 cites W2625241641 @default.
• W2892438659 cites W2735856454 @default.
• W2892438659 cites W2742917280 @default.
• W2892438659 cites W2753053398 @default.
• W2892438659 cites W2753490010 @default.
• W2892438659 cites W2759148089 @default.
• W2892438659 cites W2762354243 @default.
• W2892438659 cites W2771615156 @default.
• W2892438659 cites W2773772770 @default.
• W2892438659 cites W2774934635 @default.
• W2892438659 cites W2782431349 @default.
• W2892438659 cites W2793346766 @default.
• W2892438659 cites W2794002948 @default.
• W2892438659 cites W2794115067 @default.
• W2892438659 cites W2794200682 @default.
• W2892438659 cites W2795562305 @default.
• W2892438659 cites W2795651730 @default.
• W2892438659 cites W2795883505 @default.
• W2892438659 cites W2951438911 @default.
• W2892438659 cites W4230849949 @default.

• next