FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892448201> ?p ?o ?g. }

• W2892448201 endingPage "287" @default.
• W2892448201 startingPage "278" @default.
• W2892448201 abstract "Peptide-based vaccines have the potential to overcome the limitations of classical vaccines; however, their use is hampered by a lack of carriers and adjuvants suitable for human use. In this study, an efficient self-adjuvanting peptide vaccine delivery system was developed based on the ionic interactions between cationic trimethyl chitosan (TMC) and a peptide antigen coupled with synthetically defined anionic α-poly-(l-glutamic acid) (PGA). The antigen, possessing a conserved B-cell epitope derived from the group A streptococcus (GAS) pathogen and a universal T-helper epitope, was conjugated to PGA using cycloaddition reaction. The produced anionic conjugate formed nanoparticles (NP-1) through interaction with cationic TMC. These NP-1 induced higher systemic and mucosal antibody titers compared to antigen adjuvanted with standard mucosal adjuvant cholera toxin B subunit or antigen mixed with TMC. The produced serum antibodies were also opsonic against clinically isolated GAS strains. Further, a reduction in bacterial burden was observed in nasal secretions, pharyngeal surface and nasopharyngeal-associated lymphoid tissue of mice immunized with NP-1 in GAS challenge studies. Thus, conjugation of defined-length anionic polymer to peptide antigen as a means of formulating ionic interaction-based nanoparticles with cationic polymer is a promising strategy for peptide antigen delivery. A self-adjuvanting delivery system is required for peptide vaccines to enhance antigen delivery to immune cells and generate systemic and mucosal immunity. Herein, we developed a novel self-adjuvanting nanoparticulate delivery system for peptide antigens by combining polymer-conjugation and complexation strategies. We conjugated peptide antigen with anionic α-poly-(l-glutamic acid) that in turn, formed nanoparticles with cationic trimethyl chitosan by ionic interactions, without using external crosslinker. On intranasal administration to mice, these nanoparticles induced systemic and mucosal immunity, at low dose. Additionally, nanoparticles provided protection to vaccinated mice against group A streptococcus infection. Thus, this concept should be particularly useful in developing nanoparticles for the delivery of peptide antigens." @default.
• W2892448201 created "2018-10-05" @default.
• W2892448201 creator A5001462525 @default.
• W2892448201 creator A5005939079 @default.
• W2892448201 creator A5008581557 @default.
• W2892448201 creator A5021696238 @default.
• W2892448201 creator A5028490375 @default.
• W2892448201 creator A5035536310 @default.
• W2892448201 creator A5046282420 @default.
• W2892448201 creator A5051605057 @default.
• W2892448201 creator A5086405597 @default.
• W2892448201 date "2018-10-01" @default.
• W2892448201 modified "2023-10-03" @default.
• W2892448201 title "Polyglutamic acid-trimethyl chitosan-based intranasal peptide nano-vaccine induces potent immune responses against group A streptococcus" @default.
• W2892448201 cites W111924924 @default.
• W2892448201 cites W124239641 @default.
• W2892448201 cites W1576677426 @default.
• W2892448201 cites W1661544713 @default.
• W2892448201 cites W1751979398 @default.
• W2892448201 cites W1969603076 @default.
• W2892448201 cites W1991701295 @default.
• W2892448201 cites W2000640173 @default.
• W2892448201 cites W2003094937 @default.
• W2892448201 cites W2003983219 @default.
• W2892448201 cites W2010970450 @default.
• W2892448201 cites W2016471012 @default.
• W2892448201 cites W2019984347 @default.
• W2892448201 cites W2020019445 @default.
• W2892448201 cites W2021459906 @default.
• W2892448201 cites W2022369464 @default.
• W2892448201 cites W2028266083 @default.
• W2892448201 cites W2028762799 @default.
• W2892448201 cites W2032935112 @default.
• W2892448201 cites W2034783507 @default.
• W2892448201 cites W2044561652 @default.
• W2892448201 cites W2059201273 @default.
• W2892448201 cites W2059685308 @default.
• W2892448201 cites W2060814108 @default.
• W2892448201 cites W2071504541 @default.
• W2892448201 cites W2072316207 @default.
• W2892448201 cites W2075577776 @default.
• W2892448201 cites W2080631589 @default.
• W2892448201 cites W2085842281 @default.
• W2892448201 cites W2092070022 @default.
• W2892448201 cites W2093165790 @default.
• W2892448201 cites W2097154067 @default.
• W2892448201 cites W2111220263 @default.
• W2892448201 cites W2142947762 @default.
• W2892448201 cites W2150966363 @default.
• W2892448201 cites W2151474520 @default.
• W2892448201 cites W2167398285 @default.
• W2892448201 cites W2216203568 @default.
• W2892448201 cites W2327171017 @default.
• W2892448201 cites W2332692713 @default.
• W2892448201 cites W2338147075 @default.
• W2892448201 cites W2422529335 @default.
• W2892448201 cites W2483617431 @default.
• W2892448201 cites W2549307002 @default.
• W2892448201 cites W2624518721 @default.
• W2892448201 cites W2727473369 @default.
• W2892448201 cites W2750425581 @default.
• W2892448201 cites W2769112570 @default.
• W2892448201 cites W3091948925 @default.
• W2892448201 doi "https://doi.org/10.1016/j.actbio.2018.09.037" @default.
• W2892448201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30266637" @default.
• W2892448201 hasPublicationYear "2018" @default.
• W2892448201 type Work @default.
• W2892448201 sameAs 2892448201 @default.
• W2892448201 citedByCount "69" @default.
• W2892448201 countsByYear W28924482012019 @default.
• W2892448201 countsByYear W28924482012020 @default.
• W2892448201 countsByYear W28924482012021 @default.
• W2892448201 countsByYear W28924482012022 @default.
• W2892448201 countsByYear W28924482012023 @default.
• W2892448201 crossrefType "journal-article" @default.
• W2892448201 hasAuthorship W2892448201A5001462525 @default.
• W2892448201 hasAuthorship W2892448201A5005939079 @default.
• W2892448201 hasAuthorship W2892448201A5008581557 @default.
• W2892448201 hasAuthorship W2892448201A5021696238 @default.
• W2892448201 hasAuthorship W2892448201A5028490375 @default.
• W2892448201 hasAuthorship W2892448201A5035536310 @default.
• W2892448201 hasAuthorship W2892448201A5046282420 @default.
• W2892448201 hasAuthorship W2892448201A5051605057 @default.
• W2892448201 hasAuthorship W2892448201A5086405597 @default.
• W2892448201 hasBestOaLocation W28924482012 @default.
• W2892448201 hasConcept C134306372 @default.
• W2892448201 hasConcept C147483822 @default.
• W2892448201 hasConcept C185592680 @default.
• W2892448201 hasConcept C195616568 @default.
• W2892448201 hasConcept C197336794 @default.
• W2892448201 hasConcept C203014093 @default.
• W2892448201 hasConcept C2776207055 @default.
• W2892448201 hasConcept C2776789287 @default.
• W2892448201 hasConcept C2777863537 @default.
• W2892448201 hasConcept C2779281246 @default.
• W2892448201 hasConcept C2780868878 @default.
• W2892448201 hasConcept C33923547 @default.
• W2892448201 hasConcept C55493867 @default.

• next