FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892451531> ?p ?o ?g. }

• W2892451531 endingPage "1179" @default.
• W2892451531 startingPage "1171" @default.
• W2892451531 abstract "3,5-Bis(arylidene)-4-piperidone (BAP) derivatives display good antitumour and anti-inflammatory activities because of their double α,β-unsaturated ketone structural characteristics. If N -benzenesulfonyl substituents are introduced into BAPs, the configuration of the BAPs would change significantly and their anti-inflammatory activities should improve. Four N -benzenesulfonyl BAPs, namely (3 E ,5 E )-1-(4-methylbenzenesulfonyl)-3,5-bis[4-(trifluoromethyl)benzylidene]piperidin-4-one dichloromethane monosolvate, C 28 H 21 F 6 NO 3 S·CH 2 Cl 2 , ( 4 ), (3 E ,5 E )-1-(4-fluorobenzenesulfonyl)-3,5-bis[4-(trifluoromethyl)benzylidene]piperidin-4-one, C 27 H 18 F 7 NO 3 S, ( 5 ), (3 E ,5 E )-1-(4-nitrobenzenesulfonyl)-3,5-bis[4-(trifluoromethyl)benzylidene]piperidin-4-one, C 27 H 18 F 6 N 2 O 5 S, ( 6 ), and (3 E ,5 E )-1-(4-cyanobenzenesulfonyl)-3,5-bis[4-(trifluoromethyl)benzylidene]piperidin-4-one dichloromethane monosolvate, C 28 H 18 F 6 N 2 O 3 S·CH 2 Cl 2 , ( 7 ), were prepared by Claisen–Schmidt condensation and N -sulfonylation. They were characterized by NMR, FT–IR and HRMS (high resolution mass spectrometry). Single-crystal structure analysis reveals that the two 4-(trifluoromethyl)phenyl rings on both sides of the piperidone ring in ( 4 )–( 7 ) adopt an E stereochemistry of the olefinic double bonds. Molecules of both ( 4 ) and ( 6 ) are connected by hydrogen bonds into one-dimensional chains. In ( 5 ) and ( 7 ), pairs of adjacent molecules embrace through intermolecular hydrogen bonds to form a bimolecular combination, which are further extended into a two-dimensional sheet. The anti-inflammatory activity data reveal that ( 4 )–( 7 ) significantly inhibit LPS-induced interleukin (IL-6) and tumour necrosis factor (TNF-α) secretion. Most importantly, ( 6 ) and ( 7 ), with strong electron-withdrawing substituents, display more potential inhibitory effects than ( 4 ) and ( 5 )." @default.
• W2892451531 created "2018-10-05" @default.
• W2892451531 creator A5025616053 @default.
• W2892451531 creator A5035113347 @default.
• W2892451531 creator A5061943842 @default.
• W2892451531 creator A5085860347 @default.
• W2892451531 date "2018-09-28" @default.
• W2892451531 modified "2023-10-12" @default.
• W2892451531 title "Synthesis, crystal structures and anti-inflammatory activity of four 3,5-bis(arylidene)-N-benzenesulfonyl-4-piperidone derivatives" @default.
• W2892451531 cites W1567252384 @default.
• W2892451531 cites W1924107030 @default.
• W2892451531 cites W1942321192 @default.
• W2892451531 cites W1969360633 @default.
• W2892451531 cites W1989676628 @default.
• W2892451531 cites W1991047945 @default.
• W2892451531 cites W1998920258 @default.
• W2892451531 cites W1999702104 @default.
• W2892451531 cites W2024994751 @default.
• W2892451531 cites W2027842074 @default.
• W2892451531 cites W2047435636 @default.
• W2892451531 cites W2059277898 @default.
• W2892451531 cites W2063593425 @default.
• W2892451531 cites W2095417592 @default.
• W2892451531 cites W2102151538 @default.
• W2892451531 cites W2123105952 @default.
• W2892451531 cites W2124076790 @default.
• W2892451531 cites W2129363220 @default.
• W2892451531 cites W2131350133 @default.
• W2892451531 cites W2132454074 @default.
• W2892451531 cites W2137052325 @default.
• W2892451531 cites W2149643192 @default.
• W2892451531 cites W2181049502 @default.
• W2892451531 cites W2270213623 @default.
• W2892451531 cites W2399764660 @default.
• W2892451531 cites W2403203717 @default.
• W2892451531 cites W2510971238 @default.
• W2892451531 cites W2558504887 @default.
• W2892451531 cites W2574583579 @default.
• W2892451531 cites W2579340176 @default.
• W2892451531 cites W2753142113 @default.
• W2892451531 cites W2765477072 @default.
• W2892451531 cites W2793519975 @default.
• W2892451531 cites W2800417829 @default.
• W2892451531 doi "https://doi.org/10.1107/s2053229618013232" @default.
• W2892451531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30284984" @default.
• W2892451531 hasPublicationYear "2018" @default.
• W2892451531 type Work @default.
• W2892451531 sameAs 2892451531 @default.
• W2892451531 citedByCount "8" @default.
• W2892451531 countsByYear W28924515312019 @default.
• W2892451531 countsByYear W28924515312020 @default.
• W2892451531 countsByYear W28924515312021 @default.
• W2892451531 crossrefType "journal-article" @default.
• W2892451531 hasAuthorship W2892451531A5025616053 @default.
• W2892451531 hasAuthorship W2892451531A5035113347 @default.
• W2892451531 hasAuthorship W2892451531A5061943842 @default.
• W2892451531 hasAuthorship W2892451531A5085860347 @default.
• W2892451531 hasConcept C112887158 @default.
• W2892451531 hasConcept C115624301 @default.
• W2892451531 hasConcept C155647269 @default.
• W2892451531 hasConcept C178790620 @default.
• W2892451531 hasConcept C185592680 @default.
• W2892451531 hasConcept C2776442012 @default.
• W2892451531 hasConcept C2777738585 @default.
• W2892451531 hasConcept C2780263894 @default.
• W2892451531 hasConcept C2780378348 @default.
• W2892451531 hasConcept C2780400988 @default.
• W2892451531 hasConcept C2780471494 @default.
• W2892451531 hasConcept C32909587 @default.
• W2892451531 hasConcept C71240020 @default.
• W2892451531 hasConcept C8010536 @default.
• W2892451531 hasConceptScore W2892451531C112887158 @default.
• W2892451531 hasConceptScore W2892451531C115624301 @default.
• W2892451531 hasConceptScore W2892451531C155647269 @default.
• W2892451531 hasConceptScore W2892451531C178790620 @default.
• W2892451531 hasConceptScore W2892451531C185592680 @default.
• W2892451531 hasConceptScore W2892451531C2776442012 @default.
• W2892451531 hasConceptScore W2892451531C2777738585 @default.
• W2892451531 hasConceptScore W2892451531C2780263894 @default.
• W2892451531 hasConceptScore W2892451531C2780378348 @default.
• W2892451531 hasConceptScore W2892451531C2780400988 @default.
• W2892451531 hasConceptScore W2892451531C2780471494 @default.
• W2892451531 hasConceptScore W2892451531C32909587 @default.
• W2892451531 hasConceptScore W2892451531C71240020 @default.
• W2892451531 hasConceptScore W2892451531C8010536 @default.
• W2892451531 hasFunder F4320321001 @default.
• W2892451531 hasFunder F4320324174 @default.
• W2892451531 hasFunder F4320324321 @default.
• W2892451531 hasIssue "10" @default.
• W2892451531 hasLocation W28924515311 @default.
• W2892451531 hasLocation W28924515312 @default.
• W2892451531 hasOpenAccess W2892451531 @default.
• W2892451531 hasPrimaryLocation W28924515311 @default.
• W2892451531 hasRelatedWork W2008570602 @default.
• W2892451531 hasRelatedWork W2010892180 @default.
• W2892451531 hasRelatedWork W2040223897 @default.
• W2892451531 hasRelatedWork W2071073987 @default.
• W2892451531 hasRelatedWork W2344827765 @default.

• next