FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892457111> ?p ?o ?g. }

• W2892457111 endingPage "556" @default.
• W2892457111 startingPage "548" @default.
• W2892457111 abstract "The impact of margin status on resection of primary pancreatic neuroendocrine tumors has been poorly defined. The objectives of the present study were to determine the impact of margin status on long-term survival of patients with pancreatic neuroendocrine tumors after curative resection and evaluate the impact of reresection to obtain a microscopically negative margin.Patients who underwent curative-intent resection for pancreatic neuroendocrine tumors between 2000 and 2016 were identified at 8 hepatobiliary centers. Overall and recurrence-free survival were analyzed relative to surgical margin status using univariable and multivariable analyses.Among 1,020 patients, 866 (84.9%) had an R0 (>1 mm margin) resection, whereas 154 (15.1%) had an R1 (≤1 mm margin) resection. R1 resection was associated with a worse recurrence-free survival (10-year recurrence-free survival, R1 47.3% vs R0 62.8%, hazard ratio 1.8, 95% confidence interval 1.2-2.7, P = .002); residual tumor at either the transection margin (R1t) or the mobilization margin (R1m) was associated with increased recurrence versus R0 (R1t versus R0: hazard ratio 1.8, 95% confidence interval 1.0-3.0, P = .033; R1m versus R0: hazard ratio 1.3, 95% confidence interval 1.0-1.7, P = .060). In contrast, margin status was not associated with overall survival (10-year overall survival, R1 71.1% vs R0 71.8%, P = .392). Intraoperatively, 539 (53.6%) patients had frozen section evaluation of the surgical margin; 49 (9.1%) patients had a positive margin on frozen section analysis; 38 of the 49 patients (77.6%) had reresection, and a final R0 (secondary R0) margin was achieved in 30 patients (78.9%). Extending resection to achieve an R0 status remained associated with worse overall survival (hazard ratio 3.1, 95% confidence interval 1.6-6.2, P = .001) and recurrence-free survival (hazard ratio 2.6, 95% confidence interval 1.4-5.0, P = .004) compared with primary R0 resection. On multivariable analyses, tumor-specific factors, such as cellular differentiation, perineural invasion, Ki-67 index, and major vascular invasion, rather than surgical margin, were associated with long-term outcomes.Margin status was not associated with long-term survival. The reresection of an initially positive surgical margin to achieve a negative margin did not improve the outcome of patients with pancreatic neuroendocrine tumors. Parenchymal-sparing pancreatic procedures for pancreatic neuroendocrine tumors may be appropriate when feasible." @default.
• W2892457111 created "2018-10-05" @default.
• W2892457111 creator A5003597941 @default.
• W2892457111 creator A5004589339 @default.
• W2892457111 creator A5008282991 @default.
• W2892457111 creator A5015209246 @default.
• W2892457111 creator A5015321964 @default.
• W2892457111 creator A5016519845 @default.
• W2892457111 creator A5026126301 @default.
• W2892457111 creator A5027872333 @default.
• W2892457111 creator A5030505421 @default.
• W2892457111 creator A5034255041 @default.
• W2892457111 creator A5042876039 @default.
• W2892457111 creator A5053492781 @default.
• W2892457111 creator A5055653978 @default.
• W2892457111 creator A5057140415 @default.
• W2892457111 creator A5059255330 @default.
• W2892457111 creator A5065551581 @default.
• W2892457111 creator A5065615592 @default.
• W2892457111 creator A5073940828 @default.
• W2892457111 creator A5081302342 @default.
• W2892457111 creator A5082298309 @default.
• W2892457111 date "2019-03-01" @default.
• W2892457111 modified "2023-10-14" @default.
• W2892457111 title "Margin status and long-term prognosis of primary pancreatic neuroendocrine tumor after curative resection: Results from the US Neuroendocrine Tumor Study Group" @default.
• W2892457111 cites W1946106397 @default.
• W2892457111 cites W1964239599 @default.
• W2892457111 cites W1967459302 @default.
• W2892457111 cites W1970416124 @default.
• W2892457111 cites W1974367374 @default.
• W2892457111 cites W1980584291 @default.
• W2892457111 cites W1987453295 @default.
• W2892457111 cites W2011124745 @default.
• W2892457111 cites W2029240267 @default.
• W2892457111 cites W2035776676 @default.
• W2892457111 cites W2052145832 @default.
• W2892457111 cites W2066185056 @default.
• W2892457111 cites W2071272233 @default.
• W2892457111 cites W2079934168 @default.
• W2892457111 cites W2084301161 @default.
• W2892457111 cites W2090438424 @default.
• W2892457111 cites W2090803746 @default.
• W2892457111 cites W2118078989 @default.
• W2892457111 cites W2152387274 @default.
• W2892457111 cites W2175026653 @default.
• W2892457111 cites W2225295951 @default.
• W2892457111 cites W2343177790 @default.
• W2892457111 cites W2417056901 @default.
• W2892457111 cites W2555384272 @default.
• W2892457111 cites W2560232798 @default.
• W2892457111 cites W2570825390 @default.
• W2892457111 cites W2664800960 @default.
• W2892457111 cites W2724129713 @default.
• W2892457111 cites W2759360753 @default.
• W2892457111 cites W2790017939 @default.
• W2892457111 cites W2790862714 @default.
• W2892457111 doi "https://doi.org/10.1016/j.surg.2018.08.015" @default.
• W2892457111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30278986" @default.
• W2892457111 hasPublicationYear "2019" @default.
• W2892457111 type Work @default.
• W2892457111 sameAs 2892457111 @default.
• W2892457111 citedByCount "33" @default.
• W2892457111 countsByYear W28924571112019 @default.
• W2892457111 countsByYear W28924571112020 @default.
• W2892457111 countsByYear W28924571112021 @default.
• W2892457111 countsByYear W28924571112022 @default.
• W2892457111 countsByYear W28924571112023 @default.
• W2892457111 crossrefType "journal-article" @default.
• W2892457111 hasAuthorship W2892457111A5003597941 @default.
• W2892457111 hasAuthorship W2892457111A5004589339 @default.
• W2892457111 hasAuthorship W2892457111A5008282991 @default.
• W2892457111 hasAuthorship W2892457111A5015209246 @default.
• W2892457111 hasAuthorship W2892457111A5015321964 @default.
• W2892457111 hasAuthorship W2892457111A5016519845 @default.
• W2892457111 hasAuthorship W2892457111A5026126301 @default.
• W2892457111 hasAuthorship W2892457111A5027872333 @default.
• W2892457111 hasAuthorship W2892457111A5030505421 @default.
• W2892457111 hasAuthorship W2892457111A5034255041 @default.
• W2892457111 hasAuthorship W2892457111A5042876039 @default.
• W2892457111 hasAuthorship W2892457111A5053492781 @default.
• W2892457111 hasAuthorship W2892457111A5055653978 @default.
• W2892457111 hasAuthorship W2892457111A5057140415 @default.
• W2892457111 hasAuthorship W2892457111A5059255330 @default.
• W2892457111 hasAuthorship W2892457111A5065551581 @default.
• W2892457111 hasAuthorship W2892457111A5065615592 @default.
• W2892457111 hasAuthorship W2892457111A5073940828 @default.
• W2892457111 hasAuthorship W2892457111A5081302342 @default.
• W2892457111 hasAuthorship W2892457111A5082298309 @default.
• W2892457111 hasBestOaLocation W28924571112 @default.
• W2892457111 hasConcept C119857082 @default.
• W2892457111 hasConcept C126322002 @default.
• W2892457111 hasConcept C141071460 @default.
• W2892457111 hasConcept C159110652 @default.
• W2892457111 hasConcept C207103383 @default.
• W2892457111 hasConcept C2778132481 @default.
• W2892457111 hasConcept C2778913397 @default.
• W2892457111 hasConcept C2779066768 @default.
• W2892457111 hasConcept C41008148 @default.

• next