FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892464927> ?p ?o ?g. }

• W2892464927 abstract "Phthalates are known endocrine disruptors and found in almost all people with several associated adverse health outcomes reported in humans and animal models. Limited data are available on the relationship between exposure to endocrine disrupting chemicals and the human metabolome. We examined the relationship of metabolomic profiles in plasma and urine of 115 pregnant women with eleven urine phthalate metabolites measured at 26 weeks of gestation to identify potential biomarkers and relevant pathways. Targeted metabolomics was performed by selected reaction monitoring liquid chromatography and triple quadrupole mass spectrometry to measure 415 metabolites in plasma and 151 metabolites in urine samples. We have chosen metabolites with the best defined peaks for more detailed analysis (138 in plasma and 40 in urine). Relationship between urine phthalate metabolites and concurrent metabolomic markers in plasma and urine suggested potential involvement of diverse pathways including lipid, steroid, and nucleic acid metabolism and enhanced inflammatory response. Most of the correlations were positive for both urine and plasma, and further confirmed by regression and PCA analysis. However, after the FDR adjustment for multiple comparisons, only 9 urine associations remained statistically significant (q-values 0.0001-0.0451), including Nicotinamide mononucleotide, Cysteine T2, Cystine, and L-Aspartic acid. Additionally, we found negative associations of maternal pre-pregnancy body mass index (BMI) with more than 20 metabolomic markers related to lipid and amino-acid metabolism and inflammation pathways in plasma (p = 0.01-0.0004), while Mevalonic acid was positively associated (p = 0.009). Nicotinic acid, the only significant metabolite in urine, had a positive association with maternal BMI (p = 0.002). In summary, when evaluated in the context of metabolic pathways, the findings suggest enhanced lipid biogenesis, inflammation and altered nucleic acid metabolism in association with higher phthalate levels. These results provide new insights into the relationship between phthalates, common in most human populations, and metabolomics, a novel approach to exposure and health biomonitoring." @default.
• W2892464927 created "2018-10-05" @default.
• W2892464927 creator A5024455843 @default.
• W2892464927 creator A5030022605 @default.
• W2892464927 creator A5032298497 @default.
• W2892464927 creator A5035184259 @default.
• W2892464927 creator A5038240021 @default.
• W2892464927 creator A5043023935 @default.
• W2892464927 creator A5054541322 @default.
• W2892464927 creator A5054561346 @default.
• W2892464927 creator A5055631901 @default.
• W2892464927 creator A5079004532 @default.
• W2892464927 creator A5088765993 @default.
• W2892464927 date "2018-10-22" @default.
• W2892464927 modified "2023-10-17" @default.
• W2892464927 title "Metabolomic Markers of Phthalate Exposure in Plasma and Urine of Pregnant Women" @default.
• W2892464927 cites W107348091 @default.
• W2892464927 cites W1145903 @default.
• W2892464927 cites W1755279021 @default.
• W2892464927 cites W1877689900 @default.
• W2892464927 cites W1965283764 @default.
• W2892464927 cites W1968528693 @default.
• W2892464927 cites W1975328793 @default.
• W2892464927 cites W1976906208 @default.
• W2892464927 cites W1982185581 @default.
• W2892464927 cites W1986295047 @default.
• W2892464927 cites W1989204549 @default.
• W2892464927 cites W1994206777 @default.
• W2892464927 cites W1997062226 @default.
• W2892464927 cites W2010782635 @default.
• W2892464927 cites W2013868587 @default.
• W2892464927 cites W2014173150 @default.
• W2892464927 cites W2019913219 @default.
• W2892464927 cites W2023071064 @default.
• W2892464927 cites W2025513122 @default.
• W2892464927 cites W2031189531 @default.
• W2892464927 cites W2034573866 @default.
• W2892464927 cites W2038011036 @default.
• W2892464927 cites W2039527787 @default.
• W2892464927 cites W2044961919 @default.
• W2892464927 cites W2046738510 @default.
• W2892464927 cites W2051898539 @default.
• W2892464927 cites W2053369230 @default.
• W2892464927 cites W2053475025 @default.
• W2892464927 cites W2056250382 @default.
• W2892464927 cites W2066162989 @default.
• W2892464927 cites W2067697294 @default.
• W2892464927 cites W2068804147 @default.
• W2892464927 cites W2075442887 @default.
• W2892464927 cites W2077536826 @default.
• W2892464927 cites W2081463586 @default.
• W2892464927 cites W2087023779 @default.
• W2892464927 cites W2088562758 @default.
• W2892464927 cites W2090278635 @default.
• W2892464927 cites W2090542831 @default.
• W2892464927 cites W2097511872 @default.
• W2892464927 cites W2097633545 @default.
• W2892464927 cites W2102185269 @default.
• W2892464927 cites W2104542806 @default.
• W2892464927 cites W2111029141 @default.
• W2892464927 cites W2113063889 @default.
• W2892464927 cites W2116218899 @default.
• W2892464927 cites W2123869725 @default.
• W2892464927 cites W2130219484 @default.
• W2892464927 cites W2134307041 @default.
• W2892464927 cites W2135435176 @default.
• W2892464927 cites W2135607659 @default.
• W2892464927 cites W2139057547 @default.
• W2892464927 cites W2142930729 @default.
• W2892464927 cites W2155158051 @default.
• W2892464927 cites W2254934739 @default.
• W2892464927 cites W2294869239 @default.
• W2892464927 cites W2311022525 @default.
• W2892464927 cites W2337121958 @default.
• W2892464927 cites W2343643214 @default.
• W2892464927 cites W2345561471 @default.
• W2892464927 cites W2357535822 @default.
• W2892464927 cites W2360358288 @default.
• W2892464927 cites W2462636387 @default.
• W2892464927 cites W2474023059 @default.
• W2892464927 cites W2477459069 @default.
• W2892464927 cites W2497571386 @default.
• W2892464927 cites W2511381033 @default.
• W2892464927 cites W2513781580 @default.
• W2892464927 cites W2513887224 @default.
• W2892464927 cites W2517980469 @default.
• W2892464927 cites W2529143642 @default.
• W2892464927 cites W2534904709 @default.
• W2892464927 cites W2544635832 @default.
• W2892464927 cites W2601959191 @default.
• W2892464927 cites W2618325837 @default.
• W2892464927 cites W2803664483 @default.
• W2892464927 cites W2810150114 @default.
• W2892464927 cites W4206092243 @default.
• W2892464927 doi "https://doi.org/10.3389/fpubh.2018.00298" @default.
• W2892464927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6204535" @default.
• W2892464927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30406068" @default.
• W2892464927 hasPublicationYear "2018" @default.
• W2892464927 type Work @default.
• W2892464927 sameAs 2892464927 @default.

• next