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• W2892469848 abstract "Abstract Background Multiple sclerosis ( MS ) is an autoimmune disease of the central nervous system that, in addition to motor, sensory, and cognitive symptoms, also causes constipation, which is poorly understood. Here, we characterize gastrointestinal ( GI ) dysmotility in the experimental autoimmune encephalomyelitis ( EAE ) mouse model of MS and evaluate whether autoantibodies target the enteric nervous system ( ENS ) and cause dysmotility. Methods EAE was induced in male SJL and B6 mice. GI motility was assessed in vivo and ex vivo in wild type ( WT ) and B cell‐deficient mice. MS and EAE serum was used to survey potential targets in the ENS and changes in the ENS structure were characterized using immunohistochemistry. Key Results EAE mice developed accelerated gastric emptying and delayed whole GI transit with reduced colonic motility. Fecal water content was reduced, and colonic migrating myoelectrical complexes ( CMMC ) and slow waves were less frequent. Colons from EAE mice exhibited decreased GFAP levels in glia. Sera from MS patients and from EAE mice targeted ENS neurons and glia. B‐cell deficiency in EAE protected against colonic dysmotility. Conclusions & Inferences Consistent with symptoms experienced in MS , we demonstrate that EAE mice widely exhibit features of GI dysmotility that persisted in the absence of extrinsic innervation, suggesting direct involvement of ENS neurocircuitry. The absence of GI dysmotility in B cell‐deficient mice with EAE together with EAE and MS serum immunoreactivity against ENS targets suggests that MS could be classified among other diseases known to induce autoimmune GI dysmotility." @default.
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• W2892469848 date "2018-04-11" @default.
• W2892469848 modified "2023-10-17" @default.
• W2892469848 title "Altered gastrointestinal motility involving autoantibodies in the experimental autoimmune encephalomyelitis model of multiple sclerosis" @default.
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• W2892469848 doi "https://doi.org/10.1111/nmo.13349" @default.
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