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- W2892478638 abstract "Abstract Oxidative stress plays an important role in the pathogenesis of many disease states. In the heart, reactive oxygen species are linked with cardiac ischemia/reperfusion injury, hypertrophy, and heart failure. While this correlation between ROS and cardiac pathology has been observed in multiple models of heart failure, the independent role of hydrogen peroxide (H 2 O 2 ) in vitro and in vivo is unclear, owing to a lack of tools for precise manipulation of intracellular redox state. Here we apply a chemogenetic system based on a yeast D-amino acid oxidase to show that chronic generation of H 2 O 2 in the heart induces a dilated cardiomyopathy with significant systolic dysfunction. We anticipate that chemogenetic approaches will enable future studies of in vivo H 2 O 2 signaling not only in the heart, but also in the many other organ systems where the relationship between redox events and physiology remains unclear." @default.
- W2892478638 created "2018-10-05" @default.
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- W2892478638 date "2018-10-02" @default.
- W2892478638 modified "2023-10-12" @default.
- W2892478638 title "Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction" @default.
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- W2892478638 doi "https://doi.org/10.1038/s41467-018-06533-2" @default.
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