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• W2892489769 endingPage "136" @default.
• W2892489769 startingPage "35" @default.
• W2892489769 abstract "Innate immunity, the first line of defense against invading pathogens, is an ancient form of host defense found in all animals, from sponges to humans. During infection, innate immune receptors recognize conserved molecular patterns, such as microbial surface molecules, metabolites produces during infection, or nucleic acids of the microbe's genome. When initiated, the innate immune response activates a host defense program that leads to the synthesis proteins capable of pathogen killing. In mammals, the induction of cytokines during the innate immune response leads to the recruitment of professional immune cells to the site of infection, leading to an adaptive immune response. While a fully functional innate immune response is crucial for a proper host response and curbing microbial infection, if the innate immune response is dysfunctional and is activated in the absence of infection, autoinflammation and autoimmune disorders can develop. Therefore, it follows that the innate immune response must be tightly controlled to avoid an autoimmune response from host-derived molecules, yet still unencumbered to respond to infection. In this review, we will focus on the innate immune response activated from cytosolic nucleic acids, derived from the microbe or host itself. We will depict how viruses and bacteria activate these nucleic acid sensing pathways and their mechanisms to inhibit the pathways. We will also describe the autoinflammatory and autoimmune disorders that develop when these pathways are hyperactive. Finally, we will discuss gaps in knowledge with regard to innate immune response failure and identify where further research is needed." @default.
• W2892489769 created "2018-10-05" @default.
• W2892489769 creator A5019729601 @default.
• W2892489769 creator A5068450634 @default.
• W2892489769 creator A5083721935 @default.
• W2892489769 date "2019-01-01" @default.
• W2892489769 modified "2023-09-27" @default.
• W2892489769 title "The Role of Nucleic Acid Sensing in Controlling Microbial and Autoimmune Disorders" @default.
• W2892489769 cites W122951538 @default.
• W2892489769 cites W1451779249 @default.
• W2892489769 cites W1481088827 @default.
• W2892489769 cites W1483755648 @default.
• W2892489769 cites W1509658266 @default.
• W2892489769 cites W1513404509 @default.
• W2892489769 cites W1514540900 @default.
• W2892489769 cites W1520268659 @default.
• W2892489769 cites W1524848610 @default.
• W2892489769 cites W1547568404 @default.
• W2892489769 cites W1556684910 @default.
• W2892489769 cites W1559117436 @default.
• W2892489769 cites W1559429315 @default.
• W2892489769 cites W1581857504 @default.
• W2892489769 cites W1593341627 @default.
• W2892489769 cites W1594574415 @default.
• W2892489769 cites W1596121881 @default.
• W2892489769 cites W1599168371 @default.
• W2892489769 cites W1622454493 @default.
• W2892489769 cites W1623115463 @default.
• W2892489769 cites W1642457845 @default.
• W2892489769 cites W1667606852 @default.
• W2892489769 cites W1670573097 @default.
• W2892489769 cites W1673416641 @default.
• W2892489769 cites W1742351369 @default.
• W2892489769 cites W1774684274 @default.
• W2892489769 cites W1776390480 @default.
• W2892489769 cites W1781506009 @default.
• W2892489769 cites W1783098408 @default.
• W2892489769 cites W1808018576 @default.
• W2892489769 cites W1845637086 @default.
• W2892489769 cites W1852456295 @default.
• W2892489769 cites W1857174086 @default.
• W2892489769 cites W1857453373 @default.
• W2892489769 cites W1864392749 @default.
• W2892489769 cites W1899042388 @default.
• W2892489769 cites W1940100272 @default.
• W2892489769 cites W1964531685 @default.
• W2892489769 cites W1964641780 @default.
• W2892489769 cites W1965089560 @default.
• W2892489769 cites W1965578845 @default.
• W2892489769 cites W1965856680 @default.
• W2892489769 cites W1966270726 @default.
• W2892489769 cites W1966408457 @default.
• W2892489769 cites W1967003731 @default.
• W2892489769 cites W1968178474 @default.
• W2892489769 cites W1968182403 @default.
• W2892489769 cites W1968426124 @default.
• W2892489769 cites W1968811042 @default.
• W2892489769 cites W1968987342 @default.
• W2892489769 cites W1969072247 @default.
• W2892489769 cites W1969430178 @default.
• W2892489769 cites W1969824361 @default.
• W2892489769 cites W1969888906 @default.
• W2892489769 cites W1969968028 @default.
• W2892489769 cites W1970436087 @default.
• W2892489769 cites W1970468763 @default.
• W2892489769 cites W1971621271 @default.
• W2892489769 cites W1971757865 @default.
• W2892489769 cites W1973288627 @default.
• W2892489769 cites W1973603284 @default.
• W2892489769 cites W1973646620 @default.
• W2892489769 cites W1973773971 @default.
• W2892489769 cites W1974025441 @default.
• W2892489769 cites W1974895889 @default.
• W2892489769 cites W1975152145 @default.
• W2892489769 cites W1975873887 @default.
• W2892489769 cites W1977250512 @default.
• W2892489769 cites W1977269166 @default.
• W2892489769 cites W1977462197 @default.
• W2892489769 cites W1978210814 @default.
• W2892489769 cites W1978809200 @default.
• W2892489769 cites W1979240756 @default.
• W2892489769 cites W1979912709 @default.
• W2892489769 cites W1980284752 @default.
• W2892489769 cites W1980923315 @default.
• W2892489769 cites W1981433429 @default.
• W2892489769 cites W1981746803 @default.
• W2892489769 cites W1981837371 @default.
• W2892489769 cites W1982303898 @default.
• W2892489769 cites W1982927008 @default.
• W2892489769 cites W1982983059 @default.
• W2892489769 cites W1984443288 @default.
• W2892489769 cites W1984632540 @default.
• W2892489769 cites W1986449294 @default.
• W2892489769 cites W1986565218 @default.
• W2892489769 cites W1986772764 @default.
• W2892489769 cites W1987410025 @default.
• W2892489769 cites W1987484835 @default.
• W2892489769 cites W1987576327 @default.

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