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- W2892491188 abstract "The basic morphology of the skeleton is determined genetically, but its final mass and architecture result from epigenetic mechanisms sensitive to mechanical factors. When subjected to loading, fracture resistance depends on bone mass, material properties, geometry, and tissue quality. Osteoporotic fractures occur because reduced bone mass decreases the safety factor for skeletal loading. This results from age-related bone loss and/or failure to achieve optimal peak bone mass. It is generally believed that bone mass increases substantially during adolescence, reaching a plateau, being peak bone mass, in the late teen or young adult years. Skeletal adaptation to mechanical loading must increase bone strength without unduly increasing the metabolic cost of locomotion. During childhood and adolescence it is clear that the mechanical component of physical activity effects adaptations in the growing skeleton." @default.
- W2892491188 created "2018-10-05" @default.
- W2892491188 creator A5089104843 @default.
- W2892491188 date "2018-09-28" @default.
- W2892491188 modified "2023-09-25" @default.
- W2892491188 title "Mechanical Loading and the Developing Skeleton" @default.
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- W2892491188 doi "https://doi.org/10.1002/9781119266594.ch19" @default.
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