FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892493152> ?p ?o ?g. }

• W2892493152 endingPage "2997" @default.
• W2892493152 startingPage "2985" @default.
• W2892493152 abstract "Heterogeneity of COPD results in different therapeutic effects for different patients receiving the same treatment. COPD patients need to be individually treated according to their own characteristics. The purpose of this study was to explore the differences in different CT phenotypic COPD by molecular metabolites through the use of metabolomics.According to the characteristics of CT imaging, 42 COPD patients were grouped into phenotype E (n=20) or phenotype M (n=24). Each COPD patient received tiotropium bromide powder for inhalation for a therapeutic period of 3 months. All subjects were assigned into phenotype E in pre-therapy (EB, n=20), phenotype E in post-therapy (EA, n=20), phenotype M in pre-therapy (MB, n=22), phenotype M in post-therapy (MA, n=22), or normal control (N, n=24). The method of metabolomics based on 1H nuclear magnetic resonance (1H-NMR) was used to compare the changes in serum metabolites between COPD patients and normal controls and between different phenotypes of COPD patients in pre- and post-therapy.Patients with COPD phenotype E responded better to tiotropium bromide than patients with COPD phenotype M in terms of pulmonary function and COPD assessment test scores. There were differences in metabolites in COPD patients vs normal control people. Differences were also observed between different COPD phenotypic patients receiving the treatment in comparison with those who did not receive treatment. The changes of metabolites involved lactate, phenylalanine, fructose, glycine, asparagine, citric acid, pyruvic acid, proline, acetone, ornithine, lipid, pyridoxine, maltose, betaine, lipoprotein, and so on. These identified metabolites covered the metabolic pathways of amino acids, carbohydrates, lipids, genetic materials, and vitamin.The efficacy of tiotropium bromide on COPD phenotype E is better than that of phenotype M. Metabolites detected by 1H-NMR metabolomics have potentialities of differentiation of COPD and healthy people, discrimination of different COPD phenotypes, and giving insight into the individualized treatment of COPD." @default.
• W2892493152 created "2018-10-05" @default.
• W2892493152 creator A5005287938 @default.
• W2892493152 creator A5014598665 @default.
• W2892493152 creator A5059770499 @default.
• W2892493152 creator A5064936937 @default.
• W2892493152 creator A5074542367 @default.
• W2892493152 creator A5089822225 @default.
• W2892493152 date "2018-09-01" @default.
• W2892493152 modified "2023-09-22" @default.
• W2892493152 title "¹H-NMR-based metabolic profiling of healthy individuals and high-resolution CT-classified phenotypes of COPD with treatment of tiotropium bromide" @default.
• W2892493152 cites W1564650930 @default.
• W2892493152 cites W1658043158 @default.
• W2892493152 cites W169325176 @default.
• W2892493152 cites W1859222707 @default.
• W2892493152 cites W1904220819 @default.
• W2892493152 cites W1927591950 @default.
• W2892493152 cites W1966626343 @default.
• W2892493152 cites W1969796512 @default.
• W2892493152 cites W1970842351 @default.
• W2892493152 cites W1972864198 @default.
• W2892493152 cites W1973777808 @default.
• W2892493152 cites W2003868744 @default.
• W2892493152 cites W2023587798 @default.
• W2892493152 cites W2031898281 @default.
• W2892493152 cites W2045542983 @default.
• W2892493152 cites W2050171685 @default.
• W2892493152 cites W2052716733 @default.
• W2892493152 cites W2052741423 @default.
• W2892493152 cites W2075844360 @default.
• W2892493152 cites W2083436606 @default.
• W2892493152 cites W2097667004 @default.
• W2892493152 cites W2098418396 @default.
• W2892493152 cites W2099684592 @default.
• W2892493152 cites W2109041173 @default.
• W2892493152 cites W2120436167 @default.
• W2892493152 cites W2121008097 @default.
• W2892493152 cites W2150977134 @default.
• W2892493152 cites W2154496968 @default.
• W2892493152 cites W2157019146 @default.
• W2892493152 cites W2159505459 @default.
• W2892493152 cites W2161122384 @default.
• W2892493152 cites W2161881807 @default.
• W2892493152 cites W2165775615 @default.
• W2892493152 cites W2169729557 @default.
• W2892493152 cites W2190445875 @default.
• W2892493152 cites W2312711041 @default.
• W2892493152 cites W2408815762 @default.
• W2892493152 cites W2416780175 @default.
• W2892493152 cites W2522853764 @default.
• W2892493152 cites W2532552051 @default.
• W2892493152 cites W2773952609 @default.
• W2892493152 cites W2788071129 @default.
• W2892493152 cites W2788945727 @default.
• W2892493152 cites W2792257827 @default.
• W2892493152 doi "https://doi.org/10.2147/copd.s173264" @default.
• W2892493152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6166752" @default.
• W2892493152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30310274" @default.
• W2892493152 hasPublicationYear "2018" @default.
• W2892493152 type Work @default.
• W2892493152 sameAs 2892493152 @default.
• W2892493152 citedByCount "9" @default.
• W2892493152 countsByYear W28924931522019 @default.
• W2892493152 countsByYear W28924931522021 @default.
• W2892493152 countsByYear W28924931522022 @default.
• W2892493152 countsByYear W28924931522023 @default.
• W2892493152 crossrefType "journal-article" @default.
• W2892493152 hasAuthorship W2892493152A5005287938 @default.
• W2892493152 hasAuthorship W2892493152A5014598665 @default.
• W2892493152 hasAuthorship W2892493152A5059770499 @default.
• W2892493152 hasAuthorship W2892493152A5064936937 @default.
• W2892493152 hasAuthorship W2892493152A5074542367 @default.
• W2892493152 hasAuthorship W2892493152A5089822225 @default.
• W2892493152 hasBestOaLocation W28924931521 @default.
• W2892493152 hasConcept C104317684 @default.
• W2892493152 hasConcept C126322002 @default.
• W2892493152 hasConcept C127716648 @default.
• W2892493152 hasConcept C134018914 @default.
• W2892493152 hasConcept C2776780178 @default.
• W2892493152 hasConcept C2776968687 @default.
• W2892493152 hasConcept C2777714996 @default.
• W2892493152 hasConcept C3018587741 @default.
• W2892493152 hasConcept C55493867 @default.
• W2892493152 hasConcept C71924100 @default.
• W2892493152 hasConcept C86803240 @default.
• W2892493152 hasConcept C90924648 @default.
• W2892493152 hasConceptScore W2892493152C104317684 @default.
• W2892493152 hasConceptScore W2892493152C126322002 @default.
• W2892493152 hasConceptScore W2892493152C127716648 @default.
• W2892493152 hasConceptScore W2892493152C134018914 @default.
• W2892493152 hasConceptScore W2892493152C2776780178 @default.
• W2892493152 hasConceptScore W2892493152C2776968687 @default.
• W2892493152 hasConceptScore W2892493152C2777714996 @default.
• W2892493152 hasConceptScore W2892493152C3018587741 @default.
• W2892493152 hasConceptScore W2892493152C55493867 @default.
• W2892493152 hasConceptScore W2892493152C71924100 @default.
• W2892493152 hasConceptScore W2892493152C86803240 @default.
• W2892493152 hasConceptScore W2892493152C90924648 @default.

• next