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• W2892496157 abstract "Introduction Management of pregnant women with gestational hypertension (GH) varies according to the severity of the disease. An imbalance of soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF), is involved in pre-eclampsia (PE) pathogenesis. An elevated ratio(>110) is highly predictive of PE, whereas the diagnosis of PE can be ruled out within one week for low ratio( Objective The main objective of this study was to assess whether the cutoff value in late pregnancy (>34 weeks) help to management the preeclampsia. Methods We performed an observational study to evaluate serum sFlt-1/PlGF ratio (Roche Diagnostics Cobas e411 system) for differential diagnosis and the severity of disease from 2018 February to April (three months). Thirty-seven women with singleton pregnancies diagnosis withsuspected preeclampsia were enrolled. Serum sFlt-1 and PlGF were measured when they admitted (>34 weeks). The sFlt-1, PlGF, and the maternal clinical data were obtained. Results Among the 37 patients included, 25 had a sFlt-1/PlGF ratio lower than 38; only one diagnosis with PE leading to a negative predictive value of 96%. Two patients diagnosed with clinical PE as the ratio higher than 110. For the rest 10 patients had a sFlt-1/PlGF ratio between 38 and 110, four of them diagnosis with clinical PE. There were five patients with thrombocytopenia, the sFlt-1/PlGF ratio were all lower than 38 and rule out for HELLP. All patients were delivered without adverse maternal and neonatal outcomes. Discussion The serum sFlt-1/PlGF ratio showed highly value of differential diagnosis for ruling out PE. In our data, four of ten patients had a sFlt-1/PlGF ratio between 38 and 110 diagnosed with clinical PE, the cutoff value may be considering more clinical experience. Using these biomarkers in routine management of PE may improve clinical management of suspect patients. It need more clinical experience in future." @default.
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• W2892496157 date "2018-10-01" @default.
• W2892496157 modified "2023-09-24" @default.
• W2892496157 title "174. Evaluation of sFlt-1/PlGF ratio for improving clinical management of pre-eclampsia: Experience in a tertiary hospital" @default.
• W2892496157 doi "https://doi.org/10.1016/j.preghy.2018.08.272" @default.
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