FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892517364> ?p ?o ?g. }

• W2892517364 endingPage "3553" @default.
• W2892517364 startingPage "3539" @default.
• W2892517364 abstract "RNA binding motif protein 10 (RBM10) is a regulator of alternative splicing in apoptosis and inflammation. We discovered a splicing-independent function of RBM10 critical for the regulation of heart failure (HF). RBM10 is enriched in the heart and associates with Star-PAP (TUT1) to control the expression and 3′ end processing of cardiac mRNAs. The RBM10 RRM2 domain binds the Star-PAP catalytic domain, which directs Star-PAP activity toward polyadenylation. RBM10 binds the pre-mRNA UTR, assembles the Star-PAP complex, and guides this complex specifically to mRNAs encoding anti-hypertrophy regulators. Accordingly, we tested cellular hypertrophy in rat cardiomyoblasts and cardiac hypertrophy (CH) and the subsequent progression to HF in Wistar rat hearts. We demonstrated downregulation of RBM10 during CH and HF. Ectopic re-expression of RBM10 rescued cardiomyocyte hypertrophy. RBM10 depletion evoked a hypertrophic response in H9c2 cells. Our results establish an anti-hypertrophy mechanism mediated by RBM10 in the heart that is directly linked to HF." @default.
• W2892517364 created "2018-10-05" @default.
• W2892517364 creator A5009643341 @default.
• W2892517364 creator A5016423360 @default.
• W2892517364 creator A5032522440 @default.
• W2892517364 creator A5058340186 @default.
• W2892517364 creator A5073423903 @default.
• W2892517364 date "2018-09-01" @default.
• W2892517364 modified "2023-10-11" @default.
• W2892517364 title "A Splicing-Independent Function of RBM10 Controls Specific 3′ UTR Processing to Regulate Cardiac Hypertrophy" @default.
• W2892517364 cites W147388322 @default.
• W2892517364 cites W1762774505 @default.
• W2892517364 cites W1882377290 @default.
• W2892517364 cites W1975487818 @default.
• W2892517364 cites W1975627517 @default.
• W2892517364 cites W1979011912 @default.
• W2892517364 cites W2002083013 @default.
• W2892517364 cites W2004685609 @default.
• W2892517364 cites W2009944153 @default.
• W2892517364 cites W2015663091 @default.
• W2892517364 cites W2032419381 @default.
• W2892517364 cites W2042386784 @default.
• W2892517364 cites W2051701405 @default.
• W2892517364 cites W2051985718 @default.
• W2892517364 cites W2066825816 @default.
• W2892517364 cites W2070252006 @default.
• W2892517364 cites W2071203027 @default.
• W2892517364 cites W2074464171 @default.
• W2892517364 cites W2084671947 @default.
• W2892517364 cites W2086881404 @default.
• W2892517364 cites W2093295511 @default.
• W2892517364 cites W2094610408 @default.
• W2892517364 cites W2108244474 @default.
• W2892517364 cites W2110277124 @default.
• W2892517364 cites W2113788146 @default.
• W2892517364 cites W2122327377 @default.
• W2892517364 cites W2129439677 @default.
• W2892517364 cites W2129766349 @default.
• W2892517364 cites W2133609080 @default.
• W2892517364 cites W2133902670 @default.
• W2892517364 cites W2142824972 @default.
• W2892517364 cites W2153430526 @default.
• W2892517364 cites W2159666069 @default.
• W2892517364 cites W2204797107 @default.
• W2892517364 cites W2219687252 @default.
• W2892517364 cites W2560444797 @default.
• W2892517364 cites W2584405844 @default.
• W2892517364 cites W2622220416 @default.
• W2892517364 cites W2726628281 @default.
• W2892517364 cites W2779819699 @default.
• W2892517364 doi "https://doi.org/10.1016/j.celrep.2018.08.077" @default.
• W2892517364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30257214" @default.
• W2892517364 hasPublicationYear "2018" @default.
• W2892517364 type Work @default.
• W2892517364 sameAs 2892517364 @default.
• W2892517364 citedByCount "34" @default.
• W2892517364 countsByYear W28925173642019 @default.
• W2892517364 countsByYear W28925173642020 @default.
• W2892517364 countsByYear W28925173642021 @default.
• W2892517364 countsByYear W28925173642022 @default.
• W2892517364 countsByYear W28925173642023 @default.
• W2892517364 crossrefType "journal-article" @default.
• W2892517364 hasAuthorship W2892517364A5009643341 @default.
• W2892517364 hasAuthorship W2892517364A5016423360 @default.
• W2892517364 hasAuthorship W2892517364A5032522440 @default.
• W2892517364 hasAuthorship W2892517364A5058340186 @default.
• W2892517364 hasAuthorship W2892517364A5073423903 @default.
• W2892517364 hasBestOaLocation W28925173641 @default.
• W2892517364 hasConcept C104317684 @default.
• W2892517364 hasConcept C105580179 @default.
• W2892517364 hasConcept C126322002 @default.
• W2892517364 hasConcept C127561419 @default.
• W2892517364 hasConcept C134018914 @default.
• W2892517364 hasConcept C142575336 @default.
• W2892517364 hasConcept C167414201 @default.
• W2892517364 hasConcept C194583182 @default.
• W2892517364 hasConcept C36823959 @default.
• W2892517364 hasConcept C41282012 @default.
• W2892517364 hasConcept C54355233 @default.
• W2892517364 hasConcept C54458228 @default.
• W2892517364 hasConcept C67705224 @default.
• W2892517364 hasConcept C71924100 @default.
• W2892517364 hasConcept C86803240 @default.
• W2892517364 hasConcept C89604277 @default.
• W2892517364 hasConcept C95444343 @default.
• W2892517364 hasConcept C97037327 @default.
• W2892517364 hasConceptScore W2892517364C104317684 @default.
• W2892517364 hasConceptScore W2892517364C105580179 @default.
• W2892517364 hasConceptScore W2892517364C126322002 @default.
• W2892517364 hasConceptScore W2892517364C127561419 @default.
• W2892517364 hasConceptScore W2892517364C134018914 @default.
• W2892517364 hasConceptScore W2892517364C142575336 @default.
• W2892517364 hasConceptScore W2892517364C167414201 @default.
• W2892517364 hasConceptScore W2892517364C194583182 @default.
• W2892517364 hasConceptScore W2892517364C36823959 @default.
• W2892517364 hasConceptScore W2892517364C41282012 @default.
• W2892517364 hasConceptScore W2892517364C54355233 @default.
• W2892517364 hasConceptScore W2892517364C54458228 @default.

• next