FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892531615> ?p ?o ?g. }

• W2892531615 endingPage "1236" @default.
• W2892531615 startingPage "1232" @default.
• W2892531615 abstract "Genome-wide association studies (GWAS) have made considerable progress and there is emerging evidence that genetics-based targets can lead to 28% more launched drugs. We analyzed 1589 GWAS across 1456 pathways to translate these often imprecise genetic loci into therapeutic hypotheses for 182 diseases. These pathway-based genetic targets were validated by testing whether current drug targets were enriched in the pathway space for the same indication. Remarkably, 30% of diseases had significantly more targets in these pathways than expected by chance; the comparable number for GWAS alone (without pathway analysis) was zero. This study shows that a systematic global pathway analysis can translate genetic findings into therapeutic hypotheses for both new drug discovery and repositioning opportunities for current drugs." @default.
• W2892531615 created "2018-10-05" @default.
• W2892531615 creator A5033246609 @default.
• W2892531615 creator A5040334133 @default.
• W2892531615 creator A5072159071 @default.
• W2892531615 creator A5085530690 @default.
• W2892531615 date "2019-06-01" @default.
• W2892531615 modified "2023-10-16" @default.
• W2892531615 title "Pathway analysis of GWAS loci identifies novel drug targets and repurposing opportunities" @default.
• W2892531615 cites W1881273775 @default.
• W2892531615 cites W1967105697 @default.
• W2892531615 cites W1982945330 @default.
• W2892531615 cites W2012555794 @default.
• W2892531615 cites W2016914833 @default.
• W2892531615 cites W2025471227 @default.
• W2892531615 cites W2032947201 @default.
• W2892531615 cites W2046434400 @default.
• W2892531615 cites W2062898928 @default.
• W2892531615 cites W2118822739 @default.
• W2892531615 cites W2125972459 @default.
• W2892531615 cites W2127922938 @default.
• W2892531615 cites W2137031864 @default.
• W2892531615 cites W2148564836 @default.
• W2892531615 cites W2283903091 @default.
• W2892531615 cites W2517138451 @default.
• W2892531615 cites W2610653037 @default.
• W2892531615 cites W2725988230 @default.
• W2892531615 cites W2792611922 @default.
• W2892531615 cites W4230572836 @default.
• W2892531615 cites W57306529 @default.
• W2892531615 doi "https://doi.org/10.1016/j.drudis.2019.03.024" @default.
• W2892531615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30935985" @default.
• W2892531615 hasPublicationYear "2019" @default.
• W2892531615 type Work @default.
• W2892531615 sameAs 2892531615 @default.
• W2892531615 citedByCount "11" @default.
• W2892531615 countsByYear W28925316152019 @default.
• W2892531615 countsByYear W28925316152020 @default.
• W2892531615 countsByYear W28925316152021 @default.
• W2892531615 countsByYear W28925316152022 @default.
• W2892531615 crossrefType "journal-article" @default.
• W2892531615 hasAuthorship W2892531615A5033246609 @default.
• W2892531615 hasAuthorship W2892531615A5040334133 @default.
• W2892531615 hasAuthorship W2892531615A5072159071 @default.
• W2892531615 hasAuthorship W2892531615A5085530690 @default.
• W2892531615 hasBestOaLocation W28925316152 @default.
• W2892531615 hasConcept C103637391 @default.
• W2892531615 hasConcept C104317684 @default.
• W2892531615 hasConcept C106208931 @default.
• W2892531615 hasConcept C135763542 @default.
• W2892531615 hasConcept C153209595 @default.
• W2892531615 hasConcept C186413461 @default.
• W2892531615 hasConcept C18903297 @default.
• W2892531615 hasConcept C2780035454 @default.
• W2892531615 hasConcept C2989108626 @default.
• W2892531615 hasConcept C519536355 @default.
• W2892531615 hasConcept C54355233 @default.
• W2892531615 hasConcept C60644358 @default.
• W2892531615 hasConcept C64903051 @default.
• W2892531615 hasConcept C70721500 @default.
• W2892531615 hasConcept C74187038 @default.
• W2892531615 hasConcept C86803240 @default.
• W2892531615 hasConcept C98274493 @default.
• W2892531615 hasConceptScore W2892531615C103637391 @default.
• W2892531615 hasConceptScore W2892531615C104317684 @default.
• W2892531615 hasConceptScore W2892531615C106208931 @default.
• W2892531615 hasConceptScore W2892531615C135763542 @default.
• W2892531615 hasConceptScore W2892531615C153209595 @default.
• W2892531615 hasConceptScore W2892531615C186413461 @default.
• W2892531615 hasConceptScore W2892531615C18903297 @default.
• W2892531615 hasConceptScore W2892531615C2780035454 @default.
• W2892531615 hasConceptScore W2892531615C2989108626 @default.
• W2892531615 hasConceptScore W2892531615C519536355 @default.
• W2892531615 hasConceptScore W2892531615C54355233 @default.
• W2892531615 hasConceptScore W2892531615C60644358 @default.
• W2892531615 hasConceptScore W2892531615C64903051 @default.
• W2892531615 hasConceptScore W2892531615C70721500 @default.
• W2892531615 hasConceptScore W2892531615C74187038 @default.
• W2892531615 hasConceptScore W2892531615C86803240 @default.
• W2892531615 hasConceptScore W2892531615C98274493 @default.
• W2892531615 hasIssue "6" @default.
• W2892531615 hasLocation W28925316151 @default.
• W2892531615 hasLocation W28925316152 @default.
• W2892531615 hasLocation W28925316153 @default.
• W2892531615 hasOpenAccess W2892531615 @default.
• W2892531615 hasPrimaryLocation W28925316151 @default.
• W2892531615 hasRelatedWork W2899096130 @default.
• W2892531615 hasRelatedWork W2902729297 @default.
• W2892531615 hasRelatedWork W2959798450 @default.
• W2892531615 hasRelatedWork W3174741986 @default.
• W2892531615 hasRelatedWork W3186872001 @default.
• W2892531615 hasRelatedWork W3190782215 @default.
• W2892531615 hasRelatedWork W4206422705 @default.
• W2892531615 hasRelatedWork W4287114073 @default.
• W2892531615 hasRelatedWork W4320009247 @default.
• W2892531615 hasRelatedWork W4386502171 @default.
• W2892531615 hasVolume "24" @default.
• W2892531615 isParatext "false" @default.

• next