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- W2892534979 abstract "Recent studies show that neuroglial interactions play a key role in the regulation of complex behavior. Of particular importance is adenosine-mediated fine-tuning of glutamate neurotransmission, which modulates sleep, circadian rhythms, and alcohol intake. Astrocytic, soluble N-ethyl maleimide-sensitive fusion protein attachment protein receptor-mediated ATP release provides the extracellular adenosine that drives homeostatic sleep. Adenosine gates both photic (light-induced) glutamatergic and nonphotic (behavioral) input to the circadian clock located in the suprachiasmatic nucleus of the hypothalamus. Acute ethanol increases extracellular adenosine, which mediates the ataxic and hypnotic/sedative effects of alcohol, while chronic ethanol reduces adenosine tonus, leading to insomnia, a major predictor of relapse. Studies using mice lacking equilibrative nucleoside transporter 1 have illuminated how adenosine functions through neuroglial interactions involving glutamate uptake transporter GLT-1 (referred to as excitatory amino acid transporter 2, or EAAT2, in humans) and possibly water channel aquaporin 4 to regulate ethanol sensitivity, reward-related motivation, and alcohol intake." @default.
- W2892534979 created "2018-10-05" @default.
- W2892534979 creator A5061389073 @default.
- W2892534979 date "2015-01-01" @default.
- W2892534979 modified "2023-09-25" @default.
- W2892534979 title "Adenosine and Glutamate in Neuroglial Interaction" @default.
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- W2892534979 doi "https://doi.org/10.1016/b978-0-12-420168-2.00035-1" @default.
- W2892534979 hasPublicationYear "2015" @default.
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