Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892543033> ?p ?o ?g. }
- W2892543033 endingPage "218" @default.
- W2892543033 startingPage "204" @default.
- W2892543033 abstract "Abstract The expression of immediate early genes ( IEG s) is thought to be an essential molecular basis of neuronal plasticity for higher brain function. Many IEG s contain serum response element in their transcriptional regulatory regions and their expression is controlled by serum response factor ( SRF ). SRF is known to play a role in concert with transcriptional cofactors. However, little is known about how SRF cofactors regulate IEG expression during the process of neuronal plasticity. We hypothesized that one of the SRF ‐regulated neuronal IEG s, activity‐regulated cytoskeleton‐associated protein ( Arc ; also termed Arg3.1 ), is regulated by an SRF coactivator, megakaryoblastic leukemia ( MKL ). To test this hypothesis, we initially investigated which binding site of the transcription factor or SRF cofactor contributes to brain‐derived neurotrophic factor ( BDNF )‐induced Arc gene transcription in cultured cortical neurons using transfection and reporter assays. We found that BDNF caused robust induction of Arc gene transcription through a cAMP response element, binding site of myocyte enhancer factor 2, and binding site of SRF in an Arc enhancer, the synaptic activity‐responsive element ( SARE ). Regardless of the requirement for the SRF ‐binding site, the binding site of a ternary complex factor, another SRF cofactor, did not affect BDNF ‐mediated Arc gene transcription. In contrast, chromatin immunoprecipitation revealed occupation of MKL at the SARE . Furthermore, knockdown of MKL 2, but not MKL 1, significantly decreased BDNF ‐mediated activation of the SARE . Taken together, these findings suggest a novel mechanism by which MKL 2 controls the Arc SARE in response to BDNF stimulation. image" @default.
- W2892543033 created "2018-10-05" @default.
- W2892543033 creator A5015527024 @default.
- W2892543033 creator A5037279678 @default.
- W2892543033 creator A5038023929 @default.
- W2892543033 creator A5047951532 @default.
- W2892543033 creator A5049313379 @default.
- W2892543033 creator A5053358824 @default.
- W2892543033 creator A5056448237 @default.
- W2892543033 creator A5058080620 @default.
- W2892543033 creator A5070076495 @default.
- W2892543033 creator A5071563962 @default.
- W2892543033 creator A5073318749 @default.
- W2892543033 creator A5077052384 @default.
- W2892543033 creator A5078152665 @default.
- W2892543033 creator A5084457248 @default.
- W2892543033 date "2018-11-12" @default.
- W2892543033 modified "2023-09-30" @default.
- W2892543033 title "Involvement of SRF coactivator MKL2 in BDNF-mediated activation of the synaptic activity-responsive element in the<i>Arc</i>gene" @default.
- W2892543033 cites W1562675703 @default.
- W2892543033 cites W1607671357 @default.
- W2892543033 cites W1675950512 @default.
- W2892543033 cites W1821495885 @default.
- W2892543033 cites W1943055753 @default.
- W2892543033 cites W1965123088 @default.
- W2892543033 cites W1976480966 @default.
- W2892543033 cites W1985930923 @default.
- W2892543033 cites W1992529363 @default.
- W2892543033 cites W2006938902 @default.
- W2892543033 cites W2007662459 @default.
- W2892543033 cites W2013185658 @default.
- W2892543033 cites W2015150335 @default.
- W2892543033 cites W2017842407 @default.
- W2892543033 cites W2021885143 @default.
- W2892543033 cites W2024663595 @default.
- W2892543033 cites W2024983247 @default.
- W2892543033 cites W2026432698 @default.
- W2892543033 cites W2031177493 @default.
- W2892543033 cites W2035857873 @default.
- W2892543033 cites W2037635899 @default.
- W2892543033 cites W2038145167 @default.
- W2892543033 cites W2042834556 @default.
- W2892543033 cites W2051347917 @default.
- W2892543033 cites W2052410726 @default.
- W2892543033 cites W2060936720 @default.
- W2892543033 cites W2072500831 @default.
- W2892543033 cites W2087226217 @default.
- W2892543033 cites W2087484885 @default.
- W2892543033 cites W2091387632 @default.
- W2892543033 cites W2093723806 @default.
- W2892543033 cites W2093873997 @default.
- W2892543033 cites W2100985468 @default.
- W2892543033 cites W2102973376 @default.
- W2892543033 cites W2103288036 @default.
- W2892543033 cites W2109807917 @default.
- W2892543033 cites W2113849086 @default.
- W2892543033 cites W2120605643 @default.
- W2892543033 cites W2126772993 @default.
- W2892543033 cites W2127524138 @default.
- W2892543033 cites W2132705463 @default.
- W2892543033 cites W2133781531 @default.
- W2892543033 cites W2137346711 @default.
- W2892543033 cites W2143850042 @default.
- W2892543033 cites W2145183379 @default.
- W2892543033 cites W2152376785 @default.
- W2892543033 cites W2154900366 @default.
- W2892543033 cites W2162272208 @default.
- W2892543033 cites W2162591320 @default.
- W2892543033 cites W2170974481 @default.
- W2892543033 cites W2323319933 @default.
- W2892543033 cites W2420944975 @default.
- W2892543033 cites W2470822430 @default.
- W2892543033 cites W2607004916 @default.
- W2892543033 cites W2747083257 @default.
- W2892543033 cites W2783267015 @default.
- W2892543033 cites W4293156776 @default.
- W2892543033 doi "https://doi.org/10.1111/jnc.14596" @default.
- W2892543033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30244496" @default.
- W2892543033 hasPublicationYear "2018" @default.
- W2892543033 type Work @default.
- W2892543033 sameAs 2892543033 @default.
- W2892543033 citedByCount "8" @default.
- W2892543033 countsByYear W28925430332020 @default.
- W2892543033 countsByYear W28925430332021 @default.
- W2892543033 countsByYear W28925430332022 @default.
- W2892543033 countsByYear W28925430332023 @default.
- W2892543033 crossrefType "journal-article" @default.
- W2892543033 hasAuthorship W2892543033A5015527024 @default.
- W2892543033 hasAuthorship W2892543033A5037279678 @default.
- W2892543033 hasAuthorship W2892543033A5038023929 @default.
- W2892543033 hasAuthorship W2892543033A5047951532 @default.
- W2892543033 hasAuthorship W2892543033A5049313379 @default.
- W2892543033 hasAuthorship W2892543033A5053358824 @default.
- W2892543033 hasAuthorship W2892543033A5056448237 @default.
- W2892543033 hasAuthorship W2892543033A5058080620 @default.
- W2892543033 hasAuthorship W2892543033A5070076495 @default.
- W2892543033 hasAuthorship W2892543033A5071563962 @default.
- W2892543033 hasAuthorship W2892543033A5073318749 @default.