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• W2892543962 startingPage "937" @default.
• W2892543962 abstract "Fibrosis is a final pathological feature of many chronic diseases and available interventions specifically targeting the pathogenesis of fibrosis are lacking; natural products can solve this issue. Fibrosis develops from chronic inflammation, myofibroblast activation to EMT, and ECM accumulation, all of which can be blocked by natural products. The investigation of the pathogenesis of fibrosis indicates that interleukin, Gas6/TAM, Wnt/β-catenin, hedgehog pathway, ephrin-B2, PPARγ, lysophosphatidic acid, and CTGF are promising therapeutic targets. Natural products can target these mediators or pathways to alleviate fibrosis. Natural products have the potential to inhibit fibrosis in one organ, simultaneously targeting fibrosis in multiple other organs, which provide us new strategies to find antifibrotic drugs. The lack of well-designed randomized, placebo-controlled clinical trials and safety hinder the development and application of natural products against fibrosis in clinics. Although fibrosis is a final pathological feature of many chronic diseases, few interventions are available that specifically target the pathogenesis of fibrosis. Natural products are becoming increasingly recognized as effective therapies for fibrosis. The highlights of common cellular and molecular mechanisms of fibrosis facilitate the discovery of effective antifibrotic drugs. We describe some new profibrotic mechanisms and corresponding therapeutic targets using natural products. Interleukin, ephrin-B2, Gas6/TAM, Wnt/β-catenin, hedgehog pathway, PPARγ, lysophosphatidic acid, and CTGF are promising therapeutic targets. Natural products can target these mediators and inhibit chronic inflammation, myofibroblast activation, epithelial–mesenchymal transition, and extracellular matrix accumulation to alleviate fibrosis. Of note, natural products have the potential to inhibit fibrosis in one organ, simultaneously targeting fibrosis in multiple other organs, which provides us new strategies to find antifibrotic drugs. Although fibrosis is a final pathological feature of many chronic diseases, few interventions are available that specifically target the pathogenesis of fibrosis. Natural products are becoming increasingly recognized as effective therapies for fibrosis. The highlights of common cellular and molecular mechanisms of fibrosis facilitate the discovery of effective antifibrotic drugs. We describe some new profibrotic mechanisms and corresponding therapeutic targets using natural products. Interleukin, ephrin-B2, Gas6/TAM, Wnt/β-catenin, hedgehog pathway, PPARγ, lysophosphatidic acid, and CTGF are promising therapeutic targets. Natural products can target these mediators and inhibit chronic inflammation, myofibroblast activation, epithelial–mesenchymal transition, and extracellular matrix accumulation to alleviate fibrosis. Of note, natural products have the potential to inhibit fibrosis in one organ, simultaneously targeting fibrosis in multiple other organs, which provides us new strategies to find antifibrotic drugs. a collection of extracellular molecules. The cell adhesion, cell-to-cell communication, and cell differentiation are common functions of the ECM. In tissue fibrosis, ECM is mainly produced by myofibroblasts. a transmembrane protein that is a member of the ephrin family and is encoded by the EFNB2 gene in humans. a process by which epithelial cells lose their cell polarity and cell–cell adhesion and gain migratory and invasive properties to become mesenchymal cells, such as myofibroblasts. a family of G protein-coupled receptor proteins that serve as receptors in the Wnt signaling pathway and other signaling pathways. When activated, frizzleds lead to the activation of dishevelled in the cytosol. a group of cytokines. ILs can be divided into four major groups based on distinguishing structural features. The function of the immune system depends largely on ILs. a system of medicine with historical roots in the Indian subcontinent, which have been integrated in general wellness applications and in some cases in medical use. a phospholipid derivative that can act as a signaling molecule due to its activation of three high-affinity G protein-coupled receptors, such as the LPA1 receptor. a cell that is in between a fibroblast and a smooth muscle cell in phenotype, and during fibrosis deposits extracellular collagen fibers. a type II nuclear receptor that is encoded by the PPARG gene. PPARγ regulates fatty acid storage and glucose metabolism and attenuates fibrosis. a transcription factor that is encoded by the SNAI1 gene. Snail1 promotes the repression of the adhesion molecule E-cadherin to regulate EMT. a style of traditional medicine built on a foundation of more than 2500 years of Chinese medical practice; it is widely used in China and is becoming increasingly popular and recognized worldwide. a basic helix–loop–helix transcription factor that is encoded by the TWIST1 gene. Twist1 contributes to EMT. secreted signaling lipid modified glycoproteins that are encoded by the WNT gene family. The activation of Wnt/β-catenin contributes to fibrosis." @default.
• W2892543962 created "2018-10-05" @default.
• W2892543962 creator A5043016170 @default.
• W2892543962 creator A5070498523 @default.
• W2892543962 creator A5075079353 @default.
• W2892543962 creator A5088303852 @default.
• W2892543962 date "2018-11-01" @default.
• W2892543962 modified "2023-10-16" @default.
• W2892543962 title "Natural Products as a Source for Antifibrosis Therapy" @default.
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