Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892544206> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2892544206 abstract "Anti-NMDA receptor (NMDAR) encephalitis is a rare but severe neuropsychiatric disorder initially described by J. Dalmau and colleagues in 2007. Anti-NMDAR encephalitis is defined by a clinical picture of encephalitis associated with the presence of IgG directed against the GluN1 subunit of NMDAR (NMDAR-Abs) in the cerebrospinal fluid (CSF) of patients. This disorder predominantly affects young women. Clinical presentation usually includes psychiatric symptoms and/or neurological symptoms often accompanied by decreased responsiveness and autonomic instabilities during the course of the disease . Despite the severity of the disease, 81% of patients recover fully or with mild sequels . 38% of patients had an underlying neoplasm, 94% of which were ovarian teratomas , indicating a role for this tumor in the immunopathogenesis of the disease. Studies in vitro and on animal models have demonstrated the pathogenicity of NMDAR-Abs but more studies are required to decipher the pathological role of anti-NMDAR antibodies. Two main research focuses have emerged in our group: understanding the events leading to the immune dysregulation in the ovary teratoma and identifying the pathological element(s) and how they act at the molecular and cellular levels to cause the broad neurological spectrum of symptoms observed in patients. My PhD was especially focused on 1) understanding the involvement of the underlying ovary teratoma in the triggering of the immune response during anti-NMDAR encephalitis and 2) studying the impact of prolonged exposure of the neuronal network to patients’ NMDAR-Abs and the potential involvement of microglial cells in the physiopathology of the disease" @default.
- W2892544206 created "2018-10-05" @default.
- W2892544206 creator A5034735192 @default.
- W2892544206 date "2017-12-11" @default.
- W2892544206 modified "2023-09-23" @default.
- W2892544206 title "NMDAR Encephalitis, a model of synaptopathy" @default.
- W2892544206 hasPublicationYear "2017" @default.
- W2892544206 type Work @default.
- W2892544206 sameAs 2892544206 @default.
- W2892544206 citedByCount "0" @default.
- W2892544206 crossrefType "dissertation" @default.
- W2892544206 hasAuthorship W2892544206A5034735192 @default.
- W2892544206 hasConcept C142724271 @default.
- W2892544206 hasConcept C169760540 @default.
- W2892544206 hasConcept C203014093 @default.
- W2892544206 hasConcept C207886595 @default.
- W2892544206 hasConcept C2522874641 @default.
- W2892544206 hasConcept C2776057878 @default.
- W2892544206 hasConcept C2779134260 @default.
- W2892544206 hasConcept C2780211071 @default.
- W2892544206 hasConcept C2781460105 @default.
- W2892544206 hasConcept C2909158518 @default.
- W2892544206 hasConcept C71924100 @default.
- W2892544206 hasConcept C83455156 @default.
- W2892544206 hasConcept C86803240 @default.
- W2892544206 hasConceptScore W2892544206C142724271 @default.
- W2892544206 hasConceptScore W2892544206C169760540 @default.
- W2892544206 hasConceptScore W2892544206C203014093 @default.
- W2892544206 hasConceptScore W2892544206C207886595 @default.
- W2892544206 hasConceptScore W2892544206C2522874641 @default.
- W2892544206 hasConceptScore W2892544206C2776057878 @default.
- W2892544206 hasConceptScore W2892544206C2779134260 @default.
- W2892544206 hasConceptScore W2892544206C2780211071 @default.
- W2892544206 hasConceptScore W2892544206C2781460105 @default.
- W2892544206 hasConceptScore W2892544206C2909158518 @default.
- W2892544206 hasConceptScore W2892544206C71924100 @default.
- W2892544206 hasConceptScore W2892544206C83455156 @default.
- W2892544206 hasConceptScore W2892544206C86803240 @default.
- W2892544206 hasLocation W28925442061 @default.
- W2892544206 hasOpenAccess W2892544206 @default.
- W2892544206 hasPrimaryLocation W28925442061 @default.
- W2892544206 hasRelatedWork W1690681991 @default.
- W2892544206 hasRelatedWork W1701303852 @default.
- W2892544206 hasRelatedWork W1945164439 @default.
- W2892544206 hasRelatedWork W2006240413 @default.
- W2892544206 hasRelatedWork W2024970132 @default.
- W2892544206 hasRelatedWork W2111805863 @default.
- W2892544206 hasRelatedWork W2336934493 @default.
- W2892544206 hasRelatedWork W2545858212 @default.
- W2892544206 hasRelatedWork W2778937116 @default.
- W2892544206 hasRelatedWork W2782718662 @default.
- W2892544206 hasRelatedWork W2888599928 @default.
- W2892544206 hasRelatedWork W2889029586 @default.
- W2892544206 hasRelatedWork W2898359142 @default.
- W2892544206 hasRelatedWork W2956177188 @default.
- W2892544206 hasRelatedWork W3016837246 @default.
- W2892544206 hasRelatedWork W3030674834 @default.
- W2892544206 hasRelatedWork W3031877992 @default.
- W2892544206 hasRelatedWork W3115079956 @default.
- W2892544206 hasRelatedWork W3154468446 @default.
- W2892544206 hasRelatedWork W3203607443 @default.
- W2892544206 isParatext "false" @default.
- W2892544206 isRetracted "false" @default.
- W2892544206 magId "2892544206" @default.
- W2892544206 workType "dissertation" @default.