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- W2892546813 abstract "The prevalence of clarithromycin (CLR)-resistant Helicobacter pylori is increasing worldwide, including in Vietnam. The aims of this study were to determine point mutations in the 23S rRNA domain V of clinical H. pylori strains in central Vietnam, to estimate the prevalence of phenotypic CLR resistance and to assess the association between 23S rRNA domain V genotype and CLR-resistant phenotype. Sequencing of the 23S rRNA domain V of H. pylori strains from gastric biopsy specimens was performed for 185 patients with H. pylori-positive chronic gastritis, of which 104 samples were subjected to susceptibility testing to determine CLR resistance. A total of 24 types of point mutation were detected. A2143G and A2142G mutations were observed in 40.5% and 4.3%, respectively. New point mutations were detected (C2041T, C2083T, C2191T, G2220A, G2225A, G2240A, C2273T, T2276C, G2287A, C2399T, A2445G and C2622T). 23S rRNA domain V genotypes were diversified, with combinations of two or more point mutations as well as single point mutations. The rate of phenotypic CLR resistance was 53.8%, increasing from 40.4% in 2012–2014 to 70.2% in 2015–2017 (P = 0.0045). A2143G and A2142G accounted for 89.3% of phenotypically CLR-resistant H. pylori isolates. A diversity of point mutations in the 23S rRNA domain V was observed in clinical H. pylori isolates. The rate of phenotypically CLR-resistant H. pylori is significantly increasing in central Vietnam. Further research is necessary to clarify the role of the combination of 23S rRNA domain V mutations in the molecular mechanism of CLR resistance." @default.
- W2892546813 created "2018-10-05" @default.
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- W2892546813 date "2019-03-01" @default.
- W2892546813 modified "2023-10-16" @default.
- W2892546813 title "Characterisation of point mutations in domain V of the 23S rRNA gene of clinical Helicobacter pylori strains and clarithromycin-resistant phenotype in central Vietnam" @default.
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- W2892546813 doi "https://doi.org/10.1016/j.jgar.2018.09.012" @default.
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