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- W2892551385 abstract "Abstract Introduction Familial hypercholesterolaemia (FH) is the autosomal dominant genetic disorder most frequently associated with premature cardiovascular disease (CVD). Materials and methods A retrospective, observational study was conducted to determine the clinical characteristics, analytical parameters and cardiovascular risk factors of 133 patients with a genetically confirmed diagnosis of FH on follow-up in the Lipid Clinic of Alava. Results CVD was observed in 8.30% of the patients (ischaemic heart disease in 100% of the cases). The LDL concentration goal was achieved in 40.6% (45.50% in primary prevention and 27.30% in secondary prevention). The large majority (81.80%) of patients with coronary heart disease (CHD) were male. The odds ratio (OR) of males having CHD compared to females is 4.97 (1.03–23.93, p = 0.03). The OR of developing CHD in patients with a family history of premature CVD is 6.86 (1.32–35.67, p = p.02). A statistically significant association was found between smoking and the risk of CVD (p = 0.005), and also between having diabetes and the risk of CVD (p = 0.0001). If the treatment with statins begins at older than 40 years, the OR of suffering CHD is 6.40 (1.53–26.5) (p = 0.009). The mean time from diagnosis to the cardiovascular event in the group of ex-smokers is 10.80 ± 5.80 years, and in the non-smoking group it is 17.50 ± 2.50 years (p = 0.011). Conclusions In our reference population with FH, it was found that there was an increased risk of suffering a cardiovascular event in male patients, with a family history of premature CVD, diabetics, and in those in whom lipid lowering treatment was started after 40 years of age." @default.
- W2892551385 created "2018-10-05" @default.
- W2892551385 creator A5047309491 @default.
- W2892551385 date "2018-09-01" @default.
- W2892551385 modified "2023-09-27" @default.
- W2892551385 title "Familial hypercholesterolemia: Experience in the Lipid Clinic of Alava" @default.
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- W2892551385 doi "https://doi.org/10.1016/j.artere.2018.04.003" @default.
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