FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892552514> ?p ?o ?g. }

• W2892552514 endingPage "2994" @default.
• W2892552514 startingPage "2994" @default.
• W2892552514 abstract "Hederagenin (He) is a novel triterpene template for the development of new antitumor compounds. In this study, 26 new He–pyrazine derivatives were synthetized in an attempt to develop potent antitumor agents; they were screened for in vitro cytotoxicity against tumor and non-tumor cell lines. The majority of these derivatives showed much stronger cytotoxic activity than He. Remarkably, the most potent was compound 9 (half maximal inhibitory concentration (IC50) was 3.45 ± 0.59 μM), which exhibited similar antitumor activities against A549 (human non-small-cell lung cancer) as the positive drug cisplatin (DDP; IC50 was 3.85 ± 0.63 μM), while it showed lower cytotoxicity on H9c2 (murine heart myoblast; IC50 was 16.69 ± 0.12 μM) cell lines. Compound 9 could induce the early apoptosis and evoke cell-cycle arrest at the synthesis (S) phase of A549 cells. Impressively, we innovatively introduced the method of cluster analysis modeled as partial least squares discriminant analysis (PLS-DA) into the structure–activity relationship (SAR) evaluation, and SAR confirmed that pyrazine had a profound effect on the antitumor activity of He. The present studies highlight the importance of pyrazine derivatives of He in the discovery and development of novel antitumor agents." @default.
• W2892552514 created "2018-10-05" @default.
• W2892552514 creator A5004139768 @default.
• W2892552514 creator A5024845093 @default.
• W2892552514 creator A5028845630 @default.
• W2892552514 creator A5029930263 @default.
• W2892552514 creator A5046173951 @default.
• W2892552514 creator A5054826770 @default.
• W2892552514 creator A5056291233 @default.
• W2892552514 creator A5057014728 @default.
• W2892552514 creator A5060326988 @default.
• W2892552514 creator A5060462519 @default.
• W2892552514 creator A5079084337 @default.
• W2892552514 creator A5079969251 @default.
• W2892552514 creator A5089835448 @default.
• W2892552514 creator A5090366405 @default.
• W2892552514 date "2018-09-30" @default.
• W2892552514 modified "2023-10-14" @default.
• W2892552514 title "Design, Synthesis, and Cytotoxic Analysis of Novel Hederagenin–Pyrazine Derivatives Based on Partial Least Squares Discriminant Analysis" @default.
• W2892552514 cites W1941456578 @default.
• W2892552514 cites W1971865159 @default.
• W2892552514 cites W1980486776 @default.
• W2892552514 cites W1992928539 @default.
• W2892552514 cites W2001596696 @default.
• W2892552514 cites W2001638608 @default.
• W2892552514 cites W2005657478 @default.
• W2892552514 cites W2034694747 @default.
• W2892552514 cites W2043993495 @default.
• W2892552514 cites W2068309114 @default.
• W2892552514 cites W2109499935 @default.
• W2892552514 cites W2120565642 @default.
• W2892552514 cites W2147226476 @default.
• W2892552514 cites W2252284138 @default.
• W2892552514 cites W2297260159 @default.
• W2892552514 cites W2298274342 @default.
• W2892552514 cites W2326085958 @default.
• W2892552514 cites W2550544546 @default.
• W2892552514 cites W2588356960 @default.
• W2892552514 cites W2592654709 @default.
• W2892552514 cites W2734681302 @default.
• W2892552514 cites W2762627512 @default.
• W2892552514 cites W2766026475 @default.
• W2892552514 cites W2768540327 @default.
• W2892552514 cites W2777120500 @default.
• W2892552514 cites W2790785565 @default.
• W2892552514 cites W2806222039 @default.
• W2892552514 doi "https://doi.org/10.3390/ijms19102994" @default.
• W2892552514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213900" @default.
• W2892552514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30274380" @default.
• W2892552514 hasPublicationYear "2018" @default.
• W2892552514 type Work @default.
• W2892552514 sameAs 2892552514 @default.
• W2892552514 citedByCount "13" @default.
• W2892552514 countsByYear W28925525142019 @default.
• W2892552514 countsByYear W28925525142020 @default.
• W2892552514 countsByYear W28925525142021 @default.
• W2892552514 countsByYear W28925525142022 @default.
• W2892552514 countsByYear W28925525142023 @default.
• W2892552514 crossrefType "journal-article" @default.
• W2892552514 hasAuthorship W2892552514A5004139768 @default.
• W2892552514 hasAuthorship W2892552514A5024845093 @default.
• W2892552514 hasAuthorship W2892552514A5028845630 @default.
• W2892552514 hasAuthorship W2892552514A5029930263 @default.
• W2892552514 hasAuthorship W2892552514A5046173951 @default.
• W2892552514 hasAuthorship W2892552514A5054826770 @default.
• W2892552514 hasAuthorship W2892552514A5056291233 @default.
• W2892552514 hasAuthorship W2892552514A5057014728 @default.
• W2892552514 hasAuthorship W2892552514A5060326988 @default.
• W2892552514 hasAuthorship W2892552514A5060462519 @default.
• W2892552514 hasAuthorship W2892552514A5079084337 @default.
• W2892552514 hasAuthorship W2892552514A5079969251 @default.
• W2892552514 hasAuthorship W2892552514A5089835448 @default.
• W2892552514 hasAuthorship W2892552514A5090366405 @default.
• W2892552514 hasBestOaLocation W28925525141 @default.
• W2892552514 hasConcept C109316439 @default.
• W2892552514 hasConcept C142724271 @default.
• W2892552514 hasConcept C154317977 @default.
• W2892552514 hasConcept C185592680 @default.
• W2892552514 hasConcept C190283241 @default.
• W2892552514 hasConcept C202751555 @default.
• W2892552514 hasConcept C204787440 @default.
• W2892552514 hasConcept C2776641283 @default.
• W2892552514 hasConcept C2776694085 @default.
• W2892552514 hasConcept C2777752497 @default.
• W2892552514 hasConcept C2777765701 @default.
• W2892552514 hasConcept C2778239845 @default.
• W2892552514 hasConcept C2778858181 @default.
• W2892552514 hasConcept C29537977 @default.
• W2892552514 hasConcept C54355233 @default.
• W2892552514 hasConcept C55493867 @default.
• W2892552514 hasConcept C71240020 @default.
• W2892552514 hasConcept C71924100 @default.
• W2892552514 hasConcept C81729549 @default.
• W2892552514 hasConcept C81885089 @default.
• W2892552514 hasConcept C86803240 @default.
• W2892552514 hasConcept C98274493 @default.
• W2892552514 hasConceptScore W2892552514C109316439 @default.
• W2892552514 hasConceptScore W2892552514C142724271 @default.

• next