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- W2892573025 abstract "Actinic cheilitis (AC), a common premalignant condition related to chronic solar radiation exposure, mainly affects the lower lip of middle-aged and fair-skinned people. Histopathologic examination reveals solar elastosis and epithelial hyperplasia or dysplasia or, eventually, squamous cell carcinoma. Actinic prurigo (AP) is an idiopathic photodermatosis, with a genetic predisposition, preferentially affecting the American Mestizo population. AP is characterized by involvement of sun-exposed areas of the skin, conjunctiva, and lower lip. Histopathologic examination reveals acanthosis, spongiosis, and a dense, predominantly lymphocytic, inflammatory infiltrate, often containing well-defined lymphoid follicles and eosinophils. A 49-year-old woman was referred for an atrophic and hypopigmented area on the lower lip, which microscopically showed AP-like features. Immunohistochemically, CD3, CD8, CD20, and Ki-67 highlighted the lymphoid follicles, permeated by CD11c, CD68, CD163, FXIIIA, and HLA-DR positive cells. AC can microscopically present AP-like features; thus, a precise clinicopathologic correlation is necessary for a correct diagnosis." @default.
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- W2892573025 date "2018-09-01" @default.
- W2892573025 modified "2023-10-13" @default.
- W2892573025 title "Actinic Cheilitis Microscopically Mimicking Actinic Prurigo: an Immunohistochemical Study" @default.
- W2892573025 doi "https://doi.org/10.1016/j.oooo.2018.02.220" @default.
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