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- W2892578366 endingPage "761" @default.
- W2892578366 startingPage "761" @default.
- W2892578366 abstract "Nanotechnology has a wide range of medical and industrial applications. The impact of metallic nanoparticles (NPs) on the proliferation and differentiation of normal, cancer, and stem cells is well-studied. The preparation of NPs, along with their physicochemical properties, is related to their biological function. Interestingly, various mechanisms are implicated in metallic NP-induced cellular proliferation and differentiation, such as modulation of signaling pathways, generation of reactive oxygen species, and regulation of various transcription factors. In this review, we will shed light on the biomedical application of metallic NPs and the interaction between NPs and the cellular components. The in vitro and in vivo influence of metallic NPs on stem cell differentiation and proliferation, as well as the mechanisms behind potential toxicity, will be explored. A better understanding of the limitations related to the application of metallic NPs on stem cell proliferation and differentiation will afford clues for optimal design and preparation of metallic NPs for the modulation of stem cell functions and for clinical application in regenerative medicine." @default.
- W2892578366 created "2018-10-05" @default.
- W2892578366 creator A5005365021 @default.
- W2892578366 creator A5022409275 @default.
- W2892578366 creator A5051896735 @default.
- W2892578366 date "2018-09-26" @default.
- W2892578366 modified "2023-10-05" @default.
- W2892578366 title "The Impact of Metallic Nanoparticles on Stem Cell Proliferation and Differentiation" @default.
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