FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892581569> ?p ?o ?g. }

• W2892581569 endingPage "53" @default.
• W2892581569 startingPage "45" @default.
• W2892581569 abstract "The regulatory role of microRNAs (miRNAs) has been explored in ovarian cells, and the effects of miRNAs on gonadal development, apoptosis, ovulation, and steroid production have been reported. In this study, we analyzed the effects of follicle stimulating hormone (FSH) on miR-31 and miR-143 expression levels in bovine granulosa cells (GCs). Our results demonstrated that the FSH receptor (FSHR) is a common target gene of miR-31 and miR-143 in bovine GCs. We further analyzed the roles of miR-31 and miR-143 in bovine GCs by transfecting miR-31 and miR-143 mimics and inhibitors. The Western blot and RT-PCR results showed that miR-31 and miR-143 reduced the mRNA and protein expression levels of FSHR. Moreover, miR-31 overexpression decreased the secretion of progesterone (P4), and miR-143 overexpression decreased both the synthesis of P4 and the secretion of estrogen (E2). In contrast, miR-31 inhibition increased the secretion of progesterone (P4), and miR-143 inhibition increased both the synthesis of P4 and the secretion of E2. Finally, we analyzed the possible effects of miR-31 and miR-143 on bovine GC apoptosis. The results showed that transfection with miR-31 and miR-143 mimics promoted GC apoptosis and that miR-143 and miR-31 inhibition reduced the rate of apoptosis in bovine GCs. Taken together, our results indicate that miR-31 and miR-143 decrease steroid hormone synthesis and inhibit bovine GC apoptosis by targeting FSHR." @default.
• W2892581569 created "2018-10-05" @default.
• W2892581569 creator A5027810506 @default.
• W2892581569 creator A5028980812 @default.
• W2892581569 creator A5031114522 @default.
• W2892581569 creator A5033375004 @default.
• W2892581569 creator A5060677620 @default.
• W2892581569 creator A5065873939 @default.
• W2892581569 creator A5075101600 @default.
• W2892581569 creator A5077558876 @default.
• W2892581569 creator A5087559484 @default.
• W2892581569 date "2019-01-01" @default.
• W2892581569 modified "2023-10-02" @default.
• W2892581569 title "MiR-31 and miR-143 affect steroid hormone synthesis and inhibit cell apoptosis in bovine granulosa cells through FSHR" @default.
• W2892581569 cites W1853030099 @default.
• W2892581569 cites W1969165114 @default.
• W2892581569 cites W1969275414 @default.
• W2892581569 cites W1970152950 @default.
• W2892581569 cites W1973066064 @default.
• W2892581569 cites W1977342735 @default.
• W2892581569 cites W1980869515 @default.
• W2892581569 cites W1985282523 @default.
• W2892581569 cites W1987528944 @default.
• W2892581569 cites W1993201535 @default.
• W2892581569 cites W1996778731 @default.
• W2892581569 cites W1997096869 @default.
• W2892581569 cites W2008901904 @default.
• W2892581569 cites W2012320510 @default.
• W2892581569 cites W2012358282 @default.
• W2892581569 cites W2021320324 @default.
• W2892581569 cites W2024319734 @default.
• W2892581569 cites W2028021946 @default.
• W2892581569 cites W2032887357 @default.
• W2892581569 cites W204694583 @default.
• W2892581569 cites W2050624277 @default.
• W2892581569 cites W2061287632 @default.
• W2892581569 cites W2062401068 @default.
• W2892581569 cites W2065232902 @default.
• W2892581569 cites W2066717040 @default.
• W2892581569 cites W2071187477 @default.
• W2892581569 cites W2076221940 @default.
• W2892581569 cites W2078307923 @default.
• W2892581569 cites W2080036473 @default.
• W2892581569 cites W2080360745 @default.
• W2892581569 cites W2080418943 @default.
• W2892581569 cites W2087535311 @default.
• W2892581569 cites W2097852397 @default.
• W2892581569 cites W2099670101 @default.
• W2892581569 cites W2105354674 @default.
• W2892581569 cites W2124974256 @default.
• W2892581569 cites W2139306163 @default.
• W2892581569 cites W2144579581 @default.
• W2892581569 cites W2149332243 @default.
• W2892581569 cites W2149543418 @default.
• W2892581569 cites W2168966020 @default.
• W2892581569 cites W2259226723 @default.
• W2892581569 cites W2296288987 @default.
• W2892581569 cites W2319557481 @default.
• W2892581569 cites W2398136089 @default.
• W2892581569 cites W2474544325 @default.
• W2892581569 cites W2535737912 @default.
• W2892581569 cites W2586598941 @default.
• W2892581569 cites W2622562234 @default.
• W2892581569 cites W2664513151 @default.
• W2892581569 cites W2735145804 @default.
• W2892581569 cites W2737215659 @default.
• W2892581569 cites W2766835007 @default.
• W2892581569 cites W2800142930 @default.
• W2892581569 cites W2807331424 @default.
• W2892581569 cites W2893645357 @default.
• W2892581569 doi "https://doi.org/10.1016/j.theriogenology.2018.09.020" @default.
• W2892581569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30278258" @default.
• W2892581569 hasPublicationYear "2019" @default.
• W2892581569 type Work @default.
• W2892581569 sameAs 2892581569 @default.
• W2892581569 citedByCount "33" @default.
• W2892581569 countsByYear W28925815692020 @default.
• W2892581569 countsByYear W28925815692021 @default.
• W2892581569 countsByYear W28925815692022 @default.
• W2892581569 countsByYear W28925815692023 @default.
• W2892581569 crossrefType "journal-article" @default.
• W2892581569 hasAuthorship W2892581569A5027810506 @default.
• W2892581569 hasAuthorship W2892581569A5028980812 @default.
• W2892581569 hasAuthorship W2892581569A5031114522 @default.
• W2892581569 hasAuthorship W2892581569A5033375004 @default.
• W2892581569 hasAuthorship W2892581569A5060677620 @default.
• W2892581569 hasAuthorship W2892581569A5065873939 @default.
• W2892581569 hasAuthorship W2892581569A5075101600 @default.
• W2892581569 hasAuthorship W2892581569A5077558876 @default.
• W2892581569 hasAuthorship W2892581569A5087559484 @default.
• W2892581569 hasConcept C102570824 @default.
• W2892581569 hasConcept C104317684 @default.
• W2892581569 hasConcept C126322002 @default.
• W2892581569 hasConcept C134018914 @default.
• W2892581569 hasConcept C145059251 @default.
• W2892581569 hasConcept C185592680 @default.
• W2892581569 hasConcept C190283241 @default.
• W2892581569 hasConcept C2776415932 @default.

• next