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- W2892587514 abstract "Adenocarcinomas of salivary gland origin are malignant epithelial tumors classified according to predominant pattern of histopathologic subtyping. The diagnosis of adenocarcinoma, not otherwise specified (ANOS) is applied when the histopathologic features do not correspond to those of the defined tumor subtypes. We report a case of a 45-year-old woman presenting with a growing mass of 6 months' evolution in the left upper buccal fornix. Histopathologic analysis revealed a multinodular tumor mass comprising cuboidal to polygonal cells with few mitoses. There were numerous ducts or tubules through the tumor. The tumor cells exhibited focal perineural invasion, and sheets of tumor cells displayed pigmented cytoplasmic granules. Immunohistochemistry showed positivity for pan-cytokeratin (CK) AE1/AE3, CK7, focally for vimentin, S100, p63, D2-40, EMA, and CD56. Alpha-SMA, GFAP, p53, and HER-2/neu were negative. Ki-67 was less than 2%. The pigmented granules were positive for HMB-45 and Fontana-Masson staining. Thus, diagnosis of melanin-containing low-grade ANOS was established." @default.
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- W2892587514 date "2018-09-01" @default.
- W2892587514 modified "2023-10-16" @default.
- W2892587514 title "Intraoral Pigmented Low-Grade Adenocarcinoma, Not Otherwise Specified: an Immunohistochemical Study" @default.
- W2892587514 doi "https://doi.org/10.1016/j.oooo.2018.02.122" @default.
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