FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892596247> ?p ?o ?g. }

• W2892596247 endingPage "4738" @default.
• W2892596247 startingPage "4738" @default.
• W2892596247 abstract "Purpose: Severing of corneal nerves in preparation of corneal transplantation abolishes immune privilege of subsequent corneal transplants placed into either eye: a phenomenon termed sympathetic loss of immune privilege (SLIP). SLIP is due to the disabling of T regulatory cells (Tregs) by CD11c+ contrasuppressor (CS) cells. This study characterized the induction, function, and manipulation of CS cell activity and the effect of these cells on Tregs induced by anterior chamber-associated immune deviation (ACAID). Methods: CS cells were induced using a 2.0-mm trephine to score the corneal epithelium. CD11c+ CS cells were evaluated by adoptive transfer and by their capacity to disable CD8+ ACAID Tregs in local adoptive transfer (LAT) of suppression assays. CD11c+ cells were deleted from the ocular surface by subconjunctival injection of clodronate-containing liposomes. Results: CD11c+ CS cell were radiosenstive and long lived. As few as 1000 CS cells blocked the suppressive activity of previously generated CD8+ ACAID Tregs, indicating that CS cells act at the efferent arm of the immune response. Depletion of resident CD11c+ cells at the ocular surface prevented the generation of CS cells. Conclusions: Corneal nerve injury that occurs during keratoplasty converts ocular surface CD11c+ cells into CS cells that block CD8+ Tregs, which are induced by introducing antigens into the anterior chamber (i.e., ACAID Tregs). Depletion of CD11c+ cells at the ocular surface prevents the generation of CS cells and may be a useful strategy for preventing SLIP and enhancing the survival of second corneal transplants." @default.
• W2892596247 created "2018-10-05" @default.
• W2892596247 creator A5019891297 @default.
• W2892596247 creator A5053100719 @default.
• W2892596247 creator A5063122089 @default.
• W2892596247 creator A5073162860 @default.
• W2892596247 date "2018-09-28" @default.
• W2892596247 modified "2023-09-26" @default.
• W2892596247 title "Induction of Contrasuppressor Cells and Loss of Immune Privilege Produced by Corneal Nerve Ablation" @default.
• W2892596247 cites W1493257440 @default.
• W2892596247 cites W1554470589 @default.
• W2892596247 cites W1561045231 @default.
• W2892596247 cites W1566342733 @default.
• W2892596247 cites W1607590096 @default.
• W2892596247 cites W1697002926 @default.
• W2892596247 cites W1950309699 @default.
• W2892596247 cites W1985859986 @default.
• W2892596247 cites W1987680648 @default.
• W2892596247 cites W1998327656 @default.
• W2892596247 cites W2014870819 @default.
• W2892596247 cites W2016272979 @default.
• W2892596247 cites W2018843911 @default.
• W2892596247 cites W2025242477 @default.
• W2892596247 cites W2050092675 @default.
• W2892596247 cites W2065840171 @default.
• W2892596247 cites W2078515335 @default.
• W2892596247 cites W2111255046 @default.
• W2892596247 cites W2123987776 @default.
• W2892596247 cites W2127749729 @default.
• W2892596247 cites W2128486406 @default.
• W2892596247 cites W2130080317 @default.
• W2892596247 cites W2142263640 @default.
• W2892596247 cites W2145697808 @default.
• W2892596247 cites W2148859282 @default.
• W2892596247 cites W2169910624 @default.
• W2892596247 cites W2236375555 @default.
• W2892596247 cites W2576302407 @default.
• W2892596247 cites W4248168278 @default.
• W2892596247 cites W4255053507 @default.
• W2892596247 cites W4300438091 @default.
• W2892596247 cites W4313342346 @default.
• W2892596247 doi "https://doi.org/10.1167/iovs.18-24894" @default.
• W2892596247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6161365" @default.
• W2892596247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30267096" @default.
• W2892596247 hasPublicationYear "2018" @default.
• W2892596247 type Work @default.
• W2892596247 sameAs 2892596247 @default.
• W2892596247 citedByCount "10" @default.
• W2892596247 countsByYear W28925962472019 @default.
• W2892596247 countsByYear W28925962472020 @default.
• W2892596247 countsByYear W28925962472021 @default.
• W2892596247 countsByYear W28925962472022 @default.
• W2892596247 crossrefType "journal-article" @default.
• W2892596247 hasAuthorship W2892596247A5019891297 @default.
• W2892596247 hasAuthorship W2892596247A5053100719 @default.
• W2892596247 hasAuthorship W2892596247A5063122089 @default.
• W2892596247 hasAuthorship W2892596247A5073162860 @default.
• W2892596247 hasBestOaLocation W28925962471 @default.
• W2892596247 hasConcept C104317684 @default.
• W2892596247 hasConcept C118487528 @default.
• W2892596247 hasConcept C127716648 @default.
• W2892596247 hasConcept C167672396 @default.
• W2892596247 hasConcept C185592680 @default.
• W2892596247 hasConcept C203014093 @default.
• W2892596247 hasConcept C2776090121 @default.
• W2892596247 hasConcept C2776882836 @default.
• W2892596247 hasConcept C2779919695 @default.
• W2892596247 hasConcept C2780686511 @default.
• W2892596247 hasConcept C2781185574 @default.
• W2892596247 hasConcept C55493867 @default.
• W2892596247 hasConcept C71924100 @default.
• W2892596247 hasConcept C86803240 @default.
• W2892596247 hasConcept C8891405 @default.
• W2892596247 hasConcept C90375314 @default.
• W2892596247 hasConcept C95444343 @default.
• W2892596247 hasConceptScore W2892596247C104317684 @default.
• W2892596247 hasConceptScore W2892596247C118487528 @default.
• W2892596247 hasConceptScore W2892596247C127716648 @default.
• W2892596247 hasConceptScore W2892596247C167672396 @default.
• W2892596247 hasConceptScore W2892596247C185592680 @default.
• W2892596247 hasConceptScore W2892596247C203014093 @default.
• W2892596247 hasConceptScore W2892596247C2776090121 @default.
• W2892596247 hasConceptScore W2892596247C2776882836 @default.
• W2892596247 hasConceptScore W2892596247C2779919695 @default.
• W2892596247 hasConceptScore W2892596247C2780686511 @default.
• W2892596247 hasConceptScore W2892596247C2781185574 @default.
• W2892596247 hasConceptScore W2892596247C55493867 @default.
• W2892596247 hasConceptScore W2892596247C71924100 @default.
• W2892596247 hasConceptScore W2892596247C86803240 @default.
• W2892596247 hasConceptScore W2892596247C8891405 @default.
• W2892596247 hasConceptScore W2892596247C90375314 @default.
• W2892596247 hasConceptScore W2892596247C95444343 @default.
• W2892596247 hasIssue "11" @default.
• W2892596247 hasLocation W28925962471 @default.
• W2892596247 hasLocation W28925962472 @default.
• W2892596247 hasLocation W28925962473 @default.
• W2892596247 hasLocation W28925962474 @default.
• W2892596247 hasOpenAccess W2892596247 @default.

• next