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- W2892601008 abstract "Abstract Kidney-derived c-kit + cells exhibit progenitor/stem cell properties and can regenerate epithelial tubular cells following ischemia-reperfusion injury in rats. We therefore investigated whether c-kit + progenitor/stem cells contribute to podocyte repair in a rat model of acute proteinuria induced by puromycin aminonucleoside (PAN), the experimental prototype of human minimal change disease and early stages of focal and segmental glomerulosclerosis. We found that c-kit + progenitor/stem cells accelerated kidney recovery by improving foot process effacement (foot process width was lower in c-kit group vs saline treated animals, P = 0.03). In particular, these cells engrafted in small quantity into tubules, vessels, and glomeruli, where they occasionally differentiated into podocyte-like cells. This effect was related to an up regulation of α-Actinin-4 and mTORC2-Rictor pathway. Activation of autophagy by c-kit + progenitor/stem cells also contributed to kidney regeneration and intracellular homeostasis (autophagosomes and autophagolysosomes number and LC3A/B-I and LC3A/B-II expression were higher in the c-kit group vs saline treated animals, P = 0.0031 and P = 0.0009, respectively). Taken together, our findings suggest that kidney-derived c-kit + progenitor/stem cells exert reparative effects on glomerular disease processes through paracrine effects, to a lesser extent differentiation into podocyte-like cells and contribution to maintenance of podocyte cytoskeleton after injury. These findings have clinical implications for cell therapy of glomerular pathobiology." @default.
- W2892601008 created "2018-10-05" @default.
- W2892601008 creator A5016888338 @default.
- W2892601008 creator A5038486715 @default.
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- W2892601008 creator A5066364802 @default.
- W2892601008 creator A5068438396 @default.
- W2892601008 creator A5071821138 @default.
- W2892601008 creator A5076816264 @default.
- W2892601008 creator A5085774808 @default.
- W2892601008 date "2018-10-03" @default.
- W2892601008 modified "2023-10-10" @default.
- W2892601008 title "Kidney-derived c-kit+ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria" @default.
- W2892601008 cites W1523693806 @default.
- W2892601008 cites W1572287703 @default.
- W2892601008 cites W1600258010 @default.
- W2892601008 cites W1603299437 @default.
- W2892601008 cites W1677887083 @default.
- W2892601008 cites W1922308992 @default.
- W2892601008 cites W1930701223 @default.
- W2892601008 cites W1967588638 @default.
- W2892601008 cites W1969996031 @default.
- W2892601008 cites W1971218073 @default.
- W2892601008 cites W1973903881 @default.
- W2892601008 cites W1974146917 @default.
- W2892601008 cites W1978908434 @default.
- W2892601008 cites W1980451930 @default.
- W2892601008 cites W1987075250 @default.
- W2892601008 cites W1991207008 @default.
- W2892601008 cites W1994823455 @default.
- W2892601008 cites W1998399313 @default.
- W2892601008 cites W1999457693 @default.
- W2892601008 cites W2000915212 @default.
- W2892601008 cites W2005491635 @default.
- W2892601008 cites W2005996047 @default.
- W2892601008 cites W2012297570 @default.
- W2892601008 cites W201332785 @default.
- W2892601008 cites W2015173256 @default.
- W2892601008 cites W2016815316 @default.
- W2892601008 cites W2018676609 @default.
- W2892601008 cites W2018793121 @default.
- W2892601008 cites W2019693808 @default.
- W2892601008 cites W2023116194 @default.
- W2892601008 cites W202321997 @default.
- W2892601008 cites W2025452473 @default.
- W2892601008 cites W2025665129 @default.
- W2892601008 cites W2029216719 @default.
- W2892601008 cites W2033798110 @default.
- W2892601008 cites W2050489783 @default.
- W2892601008 cites W2051719011 @default.
- W2892601008 cites W2051784441 @default.
- W2892601008 cites W2054225562 @default.
- W2892601008 cites W2055817863 @default.
- W2892601008 cites W2055887658 @default.
- W2892601008 cites W2056462932 @default.
- W2892601008 cites W2056995253 @default.
- W2892601008 cites W2059908753 @default.
- W2892601008 cites W2059946666 @default.
- W2892601008 cites W2065258739 @default.
- W2892601008 cites W2065887259 @default.
- W2892601008 cites W2066955778 @default.
- W2892601008 cites W2069840256 @default.
- W2892601008 cites W2072802709 @default.
- W2892601008 cites W2076745740 @default.
- W2892601008 cites W2076973648 @default.
- W2892601008 cites W2085286066 @default.
- W2892601008 cites W2094156578 @default.
- W2892601008 cites W2097887036 @default.
- W2892601008 cites W2104040600 @default.
- W2892601008 cites W2105978645 @default.
- W2892601008 cites W2107705756 @default.
- W2892601008 cites W2109578526 @default.
- W2892601008 cites W2110480216 @default.
- W2892601008 cites W2111006790 @default.
- W2892601008 cites W2111533878 @default.
- W2892601008 cites W2114762453 @default.
- W2892601008 cites W2116947539 @default.
- W2892601008 cites W2124044470 @default.
- W2892601008 cites W2124476281 @default.
- W2892601008 cites W2127373567 @default.
- W2892601008 cites W2128801503 @default.
- W2892601008 cites W2130127620 @default.
- W2892601008 cites W2131978771 @default.
- W2892601008 cites W2132803823 @default.
- W2892601008 cites W2136586552 @default.
- W2892601008 cites W2137814381 @default.
- W2892601008 cites W2144807905 @default.
- W2892601008 cites W2147366467 @default.
- W2892601008 cites W2151170909 @default.
- W2892601008 cites W2152289580 @default.
- W2892601008 cites W2155431333 @default.
- W2892601008 cites W2157602761 @default.
- W2892601008 cites W2158780936 @default.
- W2892601008 cites W2159871803 @default.
- W2892601008 cites W2160588155 @default.
- W2892601008 cites W2162196137 @default.
- W2892601008 cites W2163406006 @default.
- W2892601008 cites W2166221168 @default.
- W2892601008 cites W2168044601 @default.
- W2892601008 cites W2168287443 @default.