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• W2892611619 abstract "The Autographa californica multiple nucleopolyhedrovirus (AcMNPV) ac111 gene is highly conserved in lepidopteran-specific baculoviruses, and its function in the AcMNPV life cycle is still unknown. To investigate the function of ac111, an ac111-knockout AcMNPV (vAc111KO) was constructed through homologous recombination in Escherichia coli. Viral growth curve analysis and plaque assays showed that the deletion of ac111 had no effect on infectious budded virion production. Quantitative real-time polymerase chain reaction analysis confirmed that viral DNA replication was unaffected in the absence of ac111. Electron microscopy revealed that the ac111 deletion did not affect nucleocapsid assembly, occlusion-derived virion formation, or the embedding of occlusion-derived virions into the occlusion bodies. However, in vivo bioassays showed that although the deletion of ac111 did not affect the per os infectivity of AcMNPV in Spodoptera exigua larvae, it led to an approximately five-fold reduction in infectivity of AcMNPV in Trichoplusia ni larvae, and vAc111KO took approximately 21 h longer to kill Trichoplusia ni larvae than the wild-type viruses. Taken together, our results demonstrated that although ac111 is not essential for virus replication in vitro, it plays an important role in the per os infectivity of AcMNPV in a host-dependent manner." @default.
• W2892611619 created "2018-10-05" @default.
• W2892611619 creator A5043019475 @default.
• W2892611619 creator A5073658947 @default.
• W2892611619 creator A5080196380 @default.
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• W2892611619 date "2018-09-27" @default.
• W2892611619 modified "2023-09-28" @default.
• W2892611619 title "Disruption of Autographa Californica Multiple Nucleopolyhedrovirus ac111 Results in Reduced per os Infectivity in a Host-Dependent Manner" @default.
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• W2892611619 doi "https://doi.org/10.3390/v10100527" @default.
• W2892611619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6213390" @default.
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• W2892611619 hasPublicationYear "2018" @default.
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