Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892616260> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2892616260 abstract "Background: ASXL1 gene is on chromosome region 20q11.21. Either amplification in cervical cancer or truncation mutations in colorectal cancers with microsatellite instability (MSI), malignant myeloid diseases, chronic lymphocytic leukemia, liver, prostate and breast cancers occurred. The functional and the prognostic roles of ASXL1 mutations and the expression of protein in colorectal cancer are still unknown. Aim: The aim of this study is to investigate the functional roles of ASXL1 mutations and the expression of protein in colorectal cancer. Methods: We performed NGS of 10 colorectal cancer with peritoneal seeding to find genetic markers for aggressive phenotype. All showed a frameshift deletion at codon 1934delG. To clinically validate the functional and the prognostic roles of the mutations, we performed an immunohistochemical staining (IHC) on tissue microarrays of 414 consecutive colorectal cancers. Results: The ASXL1 protein expression was strong positive in 5.8% (24 patients), moderate positive in 38.5% (157 patients) and negative in 55.6% (227 patients). The patients with negative ASXL1 expression had more lymph node metastasis than the patients with strong positive expression [59.0% (134/227 patients) vs 33.3% (8/24 patients), P = 0.038]. None of the patients with strong positive expression had recurrent disease in the stage I-III cancers [0% (0/21 patients) vs 19.4% (27/139 patients) vs 18.9% (34/180 patients)] and the disease-free survival rate of the patients with strong positive expression was significantly better than that of the patients with moderate positive or negative expression ( P = 0.037; P = 0.031). Conclusion: The decreased level of the expression of the ASXL1 protein was associated with lymph node metastasis in its progression of cancer. Strong positive ASXL1 protein expression was a 'good' prognostic factor of colorectal cancers. The ASXL1 protein might be tumor suppressive in colorectal cancer." @default.
- W2892616260 created "2018-10-05" @default.
- W2892616260 creator A5011495007 @default.
- W2892616260 date "2018-10-01" @default.
- W2892616260 modified "2023-09-23" @default.
- W2892616260 title "High Level of ASXL1 Protein Is Associated With Better Disease-Free Survival in Colorectal Cancer" @default.
- W2892616260 doi "https://doi.org/10.1200/jgo.18.80800" @default.
- W2892616260 hasPublicationYear "2018" @default.
- W2892616260 type Work @default.
- W2892616260 sameAs 2892616260 @default.
- W2892616260 citedByCount "0" @default.
- W2892616260 crossrefType "journal-article" @default.
- W2892616260 hasAuthorship W2892616260A5011495007 @default.
- W2892616260 hasBestOaLocation W28926162601 @default.
- W2892616260 hasConcept C104317684 @default.
- W2892616260 hasConcept C121608353 @default.
- W2892616260 hasConcept C126322002 @default.
- W2892616260 hasConcept C142724271 @default.
- W2892616260 hasConcept C143998085 @default.
- W2892616260 hasConcept C180754005 @default.
- W2892616260 hasConcept C193270364 @default.
- W2892616260 hasConcept C204232928 @default.
- W2892616260 hasConcept C2779767149 @default.
- W2892616260 hasConcept C502942594 @default.
- W2892616260 hasConcept C526805850 @default.
- W2892616260 hasConcept C530470458 @default.
- W2892616260 hasConcept C55493867 @default.
- W2892616260 hasConcept C61320498 @default.
- W2892616260 hasConcept C71924100 @default.
- W2892616260 hasConcept C86803240 @default.
- W2892616260 hasConceptScore W2892616260C104317684 @default.
- W2892616260 hasConceptScore W2892616260C121608353 @default.
- W2892616260 hasConceptScore W2892616260C126322002 @default.
- W2892616260 hasConceptScore W2892616260C142724271 @default.
- W2892616260 hasConceptScore W2892616260C143998085 @default.
- W2892616260 hasConceptScore W2892616260C180754005 @default.
- W2892616260 hasConceptScore W2892616260C193270364 @default.
- W2892616260 hasConceptScore W2892616260C204232928 @default.
- W2892616260 hasConceptScore W2892616260C2779767149 @default.
- W2892616260 hasConceptScore W2892616260C502942594 @default.
- W2892616260 hasConceptScore W2892616260C526805850 @default.
- W2892616260 hasConceptScore W2892616260C530470458 @default.
- W2892616260 hasConceptScore W2892616260C55493867 @default.
- W2892616260 hasConceptScore W2892616260C61320498 @default.
- W2892616260 hasConceptScore W2892616260C71924100 @default.
- W2892616260 hasConceptScore W2892616260C86803240 @default.
- W2892616260 hasLocation W28926162601 @default.
- W2892616260 hasOpenAccess W2892616260 @default.
- W2892616260 hasPrimaryLocation W28926162601 @default.
- W2892616260 hasRelatedWork W1962571516 @default.
- W2892616260 hasRelatedWork W2020048154 @default.
- W2892616260 hasRelatedWork W2038694127 @default.
- W2892616260 hasRelatedWork W2064867448 @default.
- W2892616260 hasRelatedWork W2113757208 @default.
- W2892616260 hasRelatedWork W2415539760 @default.
- W2892616260 hasRelatedWork W2560103814 @default.
- W2892616260 hasRelatedWork W2932558853 @default.
- W2892616260 hasRelatedWork W3096180069 @default.
- W2892616260 hasRelatedWork W4237412880 @default.
- W2892616260 isParatext "false" @default.
- W2892616260 isRetracted "false" @default.
- W2892616260 magId "2892616260" @default.
- W2892616260 workType "article" @default.