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• W2892616407 abstract "Aim: Polymorphisms of DNA repair enzyme gene may alter the ability to repair damage and in turn may contribute to ischemic stroke susceptibility and outcome. Methods: We selected 316 ischemic stroke patients and 302 healthy controls. Then we genotyped SNPs of PARP-1 rs3219119, rs2271347 and APE1 rs1130409 in patient and control groups. Results: Polymorphism in PARP-1 rs2271347 was significantly associated with increased ischemic stroke risk (additive model: OR: 1.74; 95% CI: 1.03–2.93; p = 0.037). Patients harboring the PARP-1 rs2271347 GA/AA genotype had a worse initial stroke (additive model: OR: 1.85; 95% CI: 1.10–3.11; p = 0.021). Conclusion: Our study suggests that genetic variant of rs2271347 may contribute to the etiology of ischemic stroke." @default.
• W2892616407 created "2018-10-05" @default.
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• W2892616407 date "2018-09-01" @default.
• W2892616407 modified "2023-09-23" @default.
• W2892616407 title "Polymorphism of <i>PARP-1</i> indicates an increased risk and a worse initial severity of ischemic stroke" @default.
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• W2892616407 doi "https://doi.org/10.2217/pme-2018-0007" @default.
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