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- W2892620829 abstract "Abstract Introduction 18 F‐fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11 C‐Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB‐R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross‐sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Results Metabolism and perfusion images were spatially correlated. Regional PiB‐R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Discussion Hypometabolism estimated by PiB‐R1 may provide a measure of brain perfusion without increasing radiation exposure." @default.
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- W2892620829 date "2018-01-01" @default.
- W2892620829 modified "2023-10-01" @default.
- W2892620829 title "Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease" @default.
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- W2892620829 doi "https://doi.org/10.1016/j.dadm.2018.08.012" @default.
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