FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892624118> ?p ?o ?g. }

• W2892624118 abstract "Living organisms need to allocate their limited resources in a manner that optimizes their overall fitness by simultaneously achieving several different biological objectives. Examination of these biological trade-offs can provide invaluable information regarding the biophysical and biochemical bases behind observed cellular phenotypes. A quantitative knowledge of a cell system’s critical objectives is also needed for engineering of cellular metabolism, where there is interest in mitigating the fitness costs that may result from human manipulation. To study metabolism in photoheterotrophs, we developed and validated a genome-scale model of metabolism in Rhodopseudomonas palustris, a metabolically versatile gram-negative purple non-sulfur bacterium capable of growing phototrophically on various carbon sources, including inorganic carbon and aromatic compounds. To quantitatively assess trade-offs among a set of important biological objectives during different metabolic growth modes, we used our new model to conduct an 8-dimensional multi-objective flux analysis of metabolism in R. palustris. Our results revealed that phototrophic metabolism in R. palustris is light-limited under anaerobic conditions, regardless of the available carbon source. Under photoheterotrophic conditions, R. palustris prioritizes the optimization of carbon efficiency, followed by ATP production and biomass production rate, in a Pareto-optimal manner. To achieve maximum carbon fixation, cells appear to divert limited energy resources away from growth and toward CO2 fixation, even in the presence of excess reduced carbon. We also found that to achieve the theoretical maximum rate of biomass production, anaerobic metabolism requires import of additional compounds (such as protons) to serve as electron acceptors. Finally, we found that production of hydrogen gas, of potential interest as a candidate biofuel, lowers the cellular growth rates under all circumstances. Photoheterotrophic metabolism of R. palustris is primarily regulated by the amount of light it can absorb and not the availability of carbon. However, despite carbon’s secondary role as a regulating factor, R. palustris’ metabolism strives for maximum carbon efficiency, even when this increased efficiency leads to slightly lower growth rates." @default.
• W2892624118 created "2018-10-05" @default.
• W2892624118 creator A5002194740 @default.
• W2892624118 creator A5014704095 @default.
• W2892624118 creator A5018562615 @default.
• W2892624118 creator A5058481329 @default.
• W2892624118 date "2019-05-09" @default.
• W2892624118 modified "2023-10-06" @default.
• W2892624118 title "System-level analysis of metabolic trade-offs during anaerobic photoheterotrophic growth in Rhodopseudomonas palustris" @default.
• W2892624118 cites W1492266779 @default.
• W2892624118 cites W1552291100 @default.
• W2892624118 cites W1557634095 @default.
• W2892624118 cites W1570937017 @default.
• W2892624118 cites W1579292960 @default.
• W2892624118 cites W1597762351 @default.
• W2892624118 cites W1603663071 @default.
• W2892624118 cites W1783673280 @default.
• W2892624118 cites W1804588670 @default.
• W2892624118 cites W1864162857 @default.
• W2892624118 cites W1904087200 @default.
• W2892624118 cites W1964990685 @default.
• W2892624118 cites W1967245901 @default.
• W2892624118 cites W1967668674 @default.
• W2892624118 cites W1970424517 @default.
• W2892624118 cites W1972748570 @default.
• W2892624118 cites W1972988221 @default.
• W2892624118 cites W1974296569 @default.
• W2892624118 cites W1975045923 @default.
• W2892624118 cites W1978687530 @default.
• W2892624118 cites W1978846818 @default.
• W2892624118 cites W1982013068 @default.
• W2892624118 cites W1985090800 @default.
• W2892624118 cites W1985778577 @default.
• W2892624118 cites W1986618453 @default.
• W2892624118 cites W1991627874 @default.
• W2892624118 cites W1992738052 @default.
• W2892624118 cites W2004506434 @default.
• W2892624118 cites W2004548026 @default.
• W2892624118 cites W2005663224 @default.
• W2892624118 cites W2006050859 @default.
• W2892624118 cites W2007467415 @default.
• W2892624118 cites W2008561466 @default.
• W2892624118 cites W2008784761 @default.
• W2892624118 cites W2010025771 @default.
• W2892624118 cites W2011728117 @default.
• W2892624118 cites W2012689220 @default.
• W2892624118 cites W2015887086 @default.
• W2892624118 cites W2019877458 @default.
• W2892624118 cites W2019908729 @default.
• W2892624118 cites W2021504381 @default.
• W2892624118 cites W2025118032 @default.
• W2892624118 cites W2034758979 @default.
• W2892624118 cites W2035146557 @default.
• W2892624118 cites W2037472558 @default.
• W2892624118 cites W2037527186 @default.
• W2892624118 cites W2040558572 @default.
• W2892624118 cites W2044935306 @default.
• W2892624118 cites W2047228180 @default.
• W2892624118 cites W2048214825 @default.
• W2892624118 cites W2048687101 @default.
• W2892624118 cites W2050281682 @default.
• W2892624118 cites W2053118024 @default.
• W2892624118 cites W2056756011 @default.
• W2892624118 cites W2060007674 @default.
• W2892624118 cites W2062245653 @default.
• W2892624118 cites W2063028509 @default.
• W2892624118 cites W2063464385 @default.
• W2892624118 cites W2064695016 @default.
• W2892624118 cites W2072620509 @default.
• W2892624118 cites W2074281688 @default.
• W2892624118 cites W2076262841 @default.
• W2892624118 cites W2078355959 @default.
• W2892624118 cites W2085993965 @default.
• W2892624118 cites W2089449076 @default.
• W2892624118 cites W2090270912 @default.
• W2892624118 cites W2093560200 @default.
• W2892624118 cites W2094730564 @default.
• W2892624118 cites W2096245011 @default.
• W2892624118 cites W2096525273 @default.
• W2892624118 cites W2098749589 @default.
• W2892624118 cites W2100084634 @default.
• W2892624118 cites W2100309737 @default.
• W2892624118 cites W2101563067 @default.
• W2892624118 cites W2101760406 @default.
• W2892624118 cites W2108709538 @default.
• W2892624118 cites W2110256992 @default.
• W2892624118 cites W2115954298 @default.
• W2892624118 cites W2117914558 @default.
• W2892624118 cites W2121688928 @default.
• W2892624118 cites W2122698404 @default.
• W2892624118 cites W2128102730 @default.
• W2892624118 cites W2128129953 @default.
• W2892624118 cites W2128737757 @default.
• W2892624118 cites W2128834757 @default.
• W2892624118 cites W2133795748 @default.
• W2892624118 cites W2134892427 @default.
• W2892624118 cites W2135343770 @default.
• W2892624118 cites W2136853888 @default.
• W2892624118 cites W2140921226 @default.
• W2892624118 cites W2142444085 @default.

• next