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- W2892625522 abstract "OBJECTIVE: We have very recently demonstrated that pioglitazone could attenuate coronary artery inflammation evaluated by 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) and computed tomography (CT) in patients with impaired glucose intolerance (IGT) or type 2 diabetes (T2DM) in a glucose-lowering independent manner. However, it remains unclear which clinical factors are associated with reduction of coronary artery inflammation. METHODS: FDG-PET and CT were performed in 47 patients with IGT or T2DM (37 males and 10 females; mean age 68.1±8.3 years). These patients were randomized to treatment with either pioglitazone or glimepiride for 16 weeks. FDG uptakes in the left main trunk and visceral fat were normalized to background blood FDG activity as target-to-background ratio (TBR) to assess coronary artery inflammation (CAI) and visceral fat metabolic activity (VFA). RESULTS: After 16-week treatments, fasting plasma glucose and HbA1c values were comparably reduced in both groups. TBR values..." @default.
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- W2892625522 date "2014-11-25" @default.
- W2892625522 modified "2023-09-26" @default.
- W2892625522 title "Abstract 12374: Visceral Fat Metabolic Activity is Independently Associated With Coronary Artery Inflammation in Patients With Impaired Glucose Intolerance or Type 2 Diabetes" @default.
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