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W2892628191 startingPage "1431" @default.
W2892628191 abstract "Abstract Artificial adipose tissue (AT) constructs are urgently needed to treat severe wounds, to replace removed tissue, or for the use as in vitro model to screen for potential drugs or study metabolic pathways. The clinical translation of products is mostly prevented by the absence of a vascular component that would allow a sustainable maintenance and an extension of the construct to a relevant size. With this study, we aimed to evaluate the suitability of a novel material based on bacterial cellulose (CBM) on the defined adipogenic differentiation of human adipose‐derived stem cells (ASCs) and the maintenance of the received adipocytes (diffASCs) and human microvascular endothelial cells (mvECs) in mono‐ and coculture. A slight acceleration of adipogenic differentiation over regular tissue culture polystyrene (TCPS) was seen on CBM under defined conditions, whereas on the maintenance of the generated adipocytes, comparable effects were detected for both materials. CBM facilitated the formation of vascular‐like structures in monoculture of mvECs, which was not observed on TCPS. By contrast, vascular‐like structures were detected in CBM and TCPS in coculture by the presence of diffASCs. Concluding, CBM represents a promising material in vascularized AT engineering with the potential to speed up and simplify the in vitro setup of engineered products. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1431–1439, 2019." @default.
W2892628191 created "2018-10-05" @default.
W2892628191 creator A5007021136 @default.
W2892628191 creator A5019134731 @default.
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W2892628191 date "2018-09-29" @default.
W2892628191 modified "2023-09-28" @default.
W2892628191 title "A cellulose‐based material for vascularized adipose tissue engineering" @default.
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W2892628191 doi "https://doi.org/10.1002/jbm.b.34235" @default.
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