FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892633090> ?p ?o ?g. }

• W2892633090 abstract "Abstract The genomic lesions found in malignant tumours exhibit a striking degree of heterogeneity. Many tumours lack a known driver mutation, and their genetic basis is unclear. By mapping the somatic mutations identified in primary lung adenocarcinomas onto an independent coexpression network derived from normal tissue, we identify a critical gene network enriched for metastasis-associated genes. While individual genes within this module were rarely mutated, a significant accumulation of mutations within this geneset was predictive of relapse in lung cancer patients that have undergone surgery. Since it is the density of mutations within this module that is informative, rather than the status of any individual gene, these data are in keeping with a ‘mini-driver’ model of tumorigenesis in which multiple mutations, each with a weak effect, combine to form a polygenic driver with sufficient power to significantly alter cell behaviour and ultimately patient outcome. These polygenic mini-drivers therefore provide a means by which heterogeneous mutation patterns can generate the consistent hallmark changes in phenotype observed across tumours." @default.
• W2892633090 created "2018-10-05" @default.
• W2892633090 creator A5002986374 @default.
• W2892633090 creator A5014084670 @default.
• W2892633090 creator A5018028692 @default.
• W2892633090 creator A5023909738 @default.
• W2892633090 creator A5055921039 @default.
• W2892633090 creator A5075517974 @default.
• W2892633090 date "2018-10-04" @default.
• W2892633090 modified "2023-10-12" @default.
• W2892633090 title "Mutation pattern analysis reveals polygenic mini-drivers associated with relapse after surgery in lung adenocarcinoma" @default.
• W2892633090 cites W1513618424 @default.
• W2892633090 cites W1530867863 @default.
• W2892633090 cites W1637197683 @default.
• W2892633090 cites W1675189444 @default.
• W2892633090 cites W1971421925 @default.
• W2892633090 cites W1983466841 @default.
• W2892633090 cites W1985213644 @default.
• W2892633090 cites W1989704868 @default.
• W2892633090 cites W2002574233 @default.
• W2892633090 cites W2006319436 @default.
• W2892633090 cites W2009720434 @default.
• W2892633090 cites W2017303659 @default.
• W2892633090 cites W2034269086 @default.
• W2892633090 cites W2037294334 @default.
• W2892633090 cites W2040847667 @default.
• W2892633090 cites W2042386784 @default.
• W2892633090 cites W2043004358 @default.
• W2892633090 cites W2044433401 @default.
• W2892633090 cites W2059145105 @default.
• W2892633090 cites W2060883703 @default.
• W2892633090 cites W2080977184 @default.
• W2892633090 cites W2102859097 @default.
• W2892633090 cites W2103017472 @default.
• W2892633090 cites W2104724027 @default.
• W2892633090 cites W2114031931 @default.
• W2892633090 cites W2126144698 @default.
• W2892633090 cites W2130410032 @default.
• W2892633090 cites W2131681506 @default.
• W2892633090 cites W2143238378 @default.
• W2892633090 cites W2145517410 @default.
• W2892633090 cites W2146871511 @default.
• W2892633090 cites W2149441684 @default.
• W2892633090 cites W2153169173 @default.
• W2892633090 cites W2164727176 @default.
• W2892633090 cites W2168303063 @default.
• W2892633090 cites W2171115585 @default.
• W2892633090 cites W2180481128 @default.
• W2892633090 cites W2194697488 @default.
• W2892633090 cites W2198703760 @default.
• W2892633090 cites W2346025119 @default.
• W2892633090 cites W2466165759 @default.
• W2892633090 cites W2545289453 @default.
• W2892633090 cites W2562536836 @default.
• W2892633090 cites W2597872842 @default.
• W2892633090 cites W2626606138 @default.
• W2892633090 cites W2747774814 @default.
• W2892633090 cites W2918086501 @default.
• W2892633090 cites W2949158494 @default.
• W2892633090 cites W4230962320 @default.
• W2892633090 doi "https://doi.org/10.1038/s41598-018-33276-3" @default.
• W2892633090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172282" @default.
• W2892633090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30287876" @default.
• W2892633090 hasPublicationYear "2018" @default.
• W2892633090 type Work @default.
• W2892633090 sameAs 2892633090 @default.
• W2892633090 citedByCount "5" @default.
• W2892633090 countsByYear W28926330902019 @default.
• W2892633090 countsByYear W28926330902022 @default.
• W2892633090 countsByYear W28926330902023 @default.
• W2892633090 crossrefType "journal-article" @default.
• W2892633090 hasAuthorship W2892633090A5002986374 @default.
• W2892633090 hasAuthorship W2892633090A5014084670 @default.
• W2892633090 hasAuthorship W2892633090A5018028692 @default.
• W2892633090 hasAuthorship W2892633090A5023909738 @default.
• W2892633090 hasAuthorship W2892633090A5055921039 @default.
• W2892633090 hasAuthorship W2892633090A5075517974 @default.
• W2892633090 hasBestOaLocation W28926330901 @default.
• W2892633090 hasConcept C104317684 @default.
• W2892633090 hasConcept C121608353 @default.
• W2892633090 hasConcept C127716648 @default.
• W2892633090 hasConcept C134305767 @default.
• W2892633090 hasConcept C143998085 @default.
• W2892633090 hasConcept C2776256026 @default.
• W2892633090 hasConcept C2779013556 @default.
• W2892633090 hasConcept C2781182431 @default.
• W2892633090 hasConcept C501734568 @default.
• W2892633090 hasConcept C54355233 @default.
• W2892633090 hasConcept C555283112 @default.
• W2892633090 hasConcept C71924100 @default.
• W2892633090 hasConcept C86803240 @default.
• W2892633090 hasConceptScore W2892633090C104317684 @default.
• W2892633090 hasConceptScore W2892633090C121608353 @default.
• W2892633090 hasConceptScore W2892633090C127716648 @default.
• W2892633090 hasConceptScore W2892633090C134305767 @default.
• W2892633090 hasConceptScore W2892633090C143998085 @default.
• W2892633090 hasConceptScore W2892633090C2776256026 @default.
• W2892633090 hasConceptScore W2892633090C2779013556 @default.
• W2892633090 hasConceptScore W2892633090C2781182431 @default.
• W2892633090 hasConceptScore W2892633090C501734568 @default.

• next