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• W2892634444 abstract "Background and Purpose— Oxidized low-density lipoprotein (oxLDL) level is thought to be associated with recurrent stroke. We aimed to investigate the association between oxLDL to high-density lipoprotein (HDL) ratio and recurrent stroke in patients with minor stroke or transient ischemic attack. Methods— The study included 3019 patients with minor ischemic stroke or high-risk transient ischemic attack from the CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events). Baseline oxLDL and HDL levels were measured. The primary outcome was any stroke within 90 days. The secondary outcomes included any stroke within 1 year and ischemic stroke and combined vascular events within 90 days and 1 year. The association between oxLDL/HDL and recurrent stroke was analyzed by using Cox proportional hazards. Results— Patients in the highest oxLDL/HDL quartile had a higher risk of recurrent stroke within 90 days (hazards ratio, 1.50; 95% CI, 1.08–2.08) compared with the lowest quartile after adjusting relevant confounding factors ( P =0.02). Similar results were found for secondary outcomes ( P <0.05 for all). There were no significant interaction between oxLDL/HDL and use of statins agents. Conclusions— Higher serum oxLDL/HDL level in minor stroke or transient ischemic attack was associated with increased risk of recurrent stroke in 90 days and 1 year. OxLDL/HDL may act as a powerful indicator of recurrent stroke in patients with minor stroke or transient ischemic attack. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00979589." @default.
• W2892634444 created "2018-10-05" @default.
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• W2892634444 date "2018-11-01" @default.
• W2892634444 modified "2023-09-25" @default.
• W2892634444 title "Oxidized Low-Density Lipoprotein to High-Density Lipoprotein Ratio Predicts Recurrent Stroke in Minor Stroke or Transient Ischemic Attack" @default.
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• W2892634444 doi "https://doi.org/10.1161/strokeaha.118.022077" @default.
• W2892634444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30355199" @default.
• W2892634444 hasPublicationYear "2018" @default.
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