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- W2892640893 abstract "We previously discovered a new osteogenic growth factor that is required to maintain adult skeletal bone mass, Osteolectin/Clec11a. Osteolectin acts on Leptin Receptor+ (LepR+) skeletal stem cells and other osteogenic progenitors in bone marrow to promote their differentiation into osteoblasts. Here we identify a receptor for Osteolectin, integrin α11, which is expressed by LepR+ cells and osteoblasts. α11β1 integrin binds Osteolectin with nanomolar affinity and is required for the osteogenic response to Osteolectin. Deletion of Itga11 (which encodes α11) from mouse and human bone marrow stromal cells impaired osteogenic differentiation and blocked their response to Osteolectin. Like Osteolectin deficient mice, Lepr-cre; Itga11fl/fl mice appeared grossly normal but exhibited reduced osteogenesis and accelerated bone loss during adulthood. Osteolectin binding to α11β1 promoted Wnt pathway activation, which was necessary for the osteogenic response to Osteolectin. This reveals a new mechanism for maintenance of adult bone mass: Wnt pathway activation by Osteolectin/α11β1 signaling." @default.
- W2892640893 created "2018-10-05" @default.
- W2892640893 creator A5005410062 @default.
- W2892640893 creator A5036469141 @default.
- W2892640893 creator A5044282878 @default.
- W2892640893 creator A5048453026 @default.
- W2892640893 creator A5054004940 @default.
- W2892640893 creator A5063756527 @default.
- W2892640893 creator A5070611989 @default.
- W2892640893 creator A5079548260 @default.
- W2892640893 date "2019-01-11" @default.
- W2892640893 modified "2023-10-18" @default.
- W2892640893 title "Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass" @default.
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