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- W2892643776 abstract "Summary Glioblastoma (GB) is the most lethal brain tumor due to its high proliferation, aggressiveness, infiltration capacity and resilience to current treatments. Activation of the Wingless-related-integration-site (WNT) pathway is associated with a bad prognosis. Using Drosophila and primary xenograft models of human GB, we describe a mechanism that leads to the activation of WNT signaling [Wingless (Wg) in Drosophila ] in tumor cells. GB cells display a network of tumor microtubes (TMs) which enwraps neurons, accumulates Wg receptor Frizzled1 (Fz1), and, thereby, actively depletes Wg from the neurons. Consequently, GB cells proliferate due to β-catenin activation, and neurons degenerate due to Wg signaling extinction. This novel view explains both neuron-dependent tumor progression, and also the neural decay associated with GB." @default.
- W2892643776 created "2018-10-05" @default.
- W2892643776 creator A5011103119 @default.
- W2892643776 creator A5016996160 @default.
- W2892643776 creator A5020893897 @default.
- W2892643776 creator A5029160758 @default.
- W2892643776 creator A5075155570 @default.
- W2892643776 creator A5085800750 @default.
- W2892643776 date "2018-09-27" @default.
- W2892643776 modified "2023-09-27" @default.
- W2892643776 title "WNT vampirization by glioblastoma leads to tumor growth and neurodegeneration" @default.
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