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• W28926443 abstract "Abstract A human lung cancer (OTUK-tumor) was transplanted serially to nude mice, which invariably developed a marked neutrophilia. In order to analyze this phenomenon, in vitro agar culture studies were carried out. A three- to fourfold increase of colony-forming units in culture was observed in the femurs of these nude mice. Moreover, the plasma of nude mice bearing this tumor, as well as the tumor extract, had a significantly higher colony-stimulating activity on mouse bone marrow cells than appropriate controls. This activity had the property to stimulate granulocyte and/or mixed cell type colonies rather than mononuclear cells. This activity was also demonstrated, in a dose- dependent way, on normal human bone marrow cells. These findings indicated that the OTUK-tumor produced human granulopoietic colony- stimulating activity, which may have stimulated granulopoiesis in vivo as well." @default.
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• W28926443 date "1977-05-01" @default.
• W28926443 modified "2023-10-09" @default.
• W28926443 title "Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue" @default.
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• W28926443 doi "https://doi.org/10.1182/blood.v49.5.845.845" @default.
• W28926443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/300638" @default.
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