FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892646415> ?p ?o ?g. }

• W2892646415 endingPage "155" @default.
• W2892646415 startingPage "155" @default.
• W2892646415 abstract "The field of pharmacogenomics seeks to understand how an individual's unique gene sequence can affect their response to certain drugs. It is particularly relevant in anesthesia when the interindividual response to pain medication is essential. Codeine and tramadol are prodrugs metabolized by CYP2D6, polymorphisms of which can cause dangerous or even fatal levels of their metabolites, or decrease the level of metabolites to decrease their analgesic effect. Many other opioids are metabolized by CYP2D6 or CYP3A5, of which loss-of-function variants can cause dangerous levels of these drugs. The OCT1 transporter facilitates the movement of drugs into hepatocytes for metabolism, and variants of this transporter can increase serum levels of morphine and O-desmethyltramadol. Many NSAIDs are metabolized by CYP2C9, and there is concern that variants of this enzyme may lead to high serum levels of these drugs, causing gastrointestinal bleeding, however the data does not strongly support this. The ABCB1 gene encodes for P-glycoprotein which facilitates efflux of opioids away from their target receptors. The C3435T SNP may increase the concentration of opioids at target receptors, although the data is not conclusive. Catechol-O-Methyltransferase (COMT) is shown to indirectly upregulate opioid receptors. Certain haplotypes of COMT have been demonstrated to have an effect on opioid requirements. The OPRM1 gene codes for the mu-opioid receptor, and there is conflicting data regarding its effect on analgesia and opioid requirements. Overall, there is a fair amount of conflicting data in the above topics, suggesting that there is still a lot of research to be done on these topics, and that pain perception is multifactorial, likely including many common genetic variants." @default.
• W2892646415 created "2018-10-05" @default.
• W2892646415 creator A5060011759 @default.
• W2892646415 creator A5063440834 @default.
• W2892646415 date "2018-01-01" @default.
• W2892646415 modified "2023-10-05" @default.
• W2892646415 title "Pharmacogenomics of analgesics in anesthesia practice: A current update of literature" @default.
• W2892646415 cites W1564580398 @default.
• W2892646415 cites W1896034128 @default.
• W2892646415 cites W1913088868 @default.
• W2892646415 cites W1965228291 @default.
• W2892646415 cites W1968139217 @default.
• W2892646415 cites W1968272849 @default.
• W2892646415 cites W1968814844 @default.
• W2892646415 cites W1973128804 @default.
• W2892646415 cites W1973459298 @default.
• W2892646415 cites W1975461227 @default.
• W2892646415 cites W1976140947 @default.
• W2892646415 cites W1981468629 @default.
• W2892646415 cites W1983877031 @default.
• W2892646415 cites W1983989752 @default.
• W2892646415 cites W1985327494 @default.
• W2892646415 cites W1987687706 @default.
• W2892646415 cites W1989956851 @default.
• W2892646415 cites W1991567206 @default.
• W2892646415 cites W1992411006 @default.
• W2892646415 cites W1999562377 @default.
• W2892646415 cites W2002612293 @default.
• W2892646415 cites W2006582768 @default.
• W2892646415 cites W2008825099 @default.
• W2892646415 cites W2009176168 @default.
• W2892646415 cites W2009582258 @default.
• W2892646415 cites W2010438139 @default.
• W2892646415 cites W2012743573 @default.
• W2892646415 cites W2014405410 @default.
• W2892646415 cites W2016124588 @default.
• W2892646415 cites W2018608742 @default.
• W2892646415 cites W2022077625 @default.
• W2892646415 cites W2022797906 @default.
• W2892646415 cites W2027280333 @default.
• W2892646415 cites W2035133162 @default.
• W2892646415 cites W2036403536 @default.
• W2892646415 cites W2038398498 @default.
• W2892646415 cites W2041845059 @default.
• W2892646415 cites W2043331535 @default.
• W2892646415 cites W2043527756 @default.
• W2892646415 cites W2047737161 @default.
• W2892646415 cites W2049583185 @default.
• W2892646415 cites W2049595315 @default.
• W2892646415 cites W2056152291 @default.
• W2892646415 cites W2057709147 @default.
• W2892646415 cites W2058239752 @default.
• W2892646415 cites W2065775206 @default.
• W2892646415 cites W2068236460 @default.
• W2892646415 cites W2068773272 @default.
• W2892646415 cites W2070921940 @default.
• W2892646415 cites W2074480733 @default.
• W2892646415 cites W2074524706 @default.
• W2892646415 cites W2077037471 @default.
• W2892646415 cites W2080822069 @default.
• W2892646415 cites W2083629908 @default.
• W2892646415 cites W2086185646 @default.
• W2892646415 cites W2088216581 @default.
• W2892646415 cites W2091212941 @default.
• W2892646415 cites W2094585402 @default.
• W2892646415 cites W2099953867 @default.
• W2892646415 cites W2101443067 @default.
• W2892646415 cites W2102728492 @default.
• W2892646415 cites W2107955043 @default.
• W2892646415 cites W2114629307 @default.
• W2892646415 cites W2123390254 @default.
• W2892646415 cites W2124448589 @default.
• W2892646415 cites W2131131247 @default.
• W2892646415 cites W2135163551 @default.
• W2892646415 cites W2141630515 @default.
• W2892646415 cites W2142227328 @default.
• W2892646415 cites W2143552539 @default.
• W2892646415 cites W2148948931 @default.
• W2892646415 cites W2159542081 @default.
• W2892646415 cites W2161526651 @default.
• W2892646415 cites W2165819346 @default.
• W2892646415 cites W2169653268 @default.
• W2892646415 cites W2290456508 @default.
• W2892646415 cites W2444549870 @default.
• W2892646415 doi "https://doi.org/10.4103/joacp.joacp_319_17" @default.
• W2892646415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6066884" @default.
• W2892646415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30104820" @default.
• W2892646415 hasPublicationYear "2018" @default.
• W2892646415 type Work @default.
• W2892646415 sameAs 2892646415 @default.
• W2892646415 citedByCount "18" @default.
• W2892646415 countsByYear W28926464152019 @default.
• W2892646415 countsByYear W28926464152020 @default.
• W2892646415 countsByYear W28926464152021 @default.
• W2892646415 countsByYear W28926464152022 @default.
• W2892646415 countsByYear W28926464152023 @default.
• W2892646415 crossrefType "journal-article" @default.
• W2892646415 hasAuthorship W2892646415A5060011759 @default.

• next