Matches in SemOpenAlex for { <https://semopenalex.org/work/W2892647771> ?p ?o ?g. }
- W2892647771 abstract "Abstract Promoters and enhancers—key controllers of gene expression—have long been distinguished from each other based on their function. However, recent work suggested that common architectural and functional features might have facilitated the conversion of one type of element into the other during evolution. Here, based on cross-mammalian analyses of epigenome and transcriptome data, we provide support for this hypothesis by detecting 445 regulatory elements with signatures of activity turnover (termed P/E elements). Most events represent transformations of putative ancestral enhancers into promoters, leading to the emergence of species-specific transcribed loci or 5′ exons. Distinct GC sequence compositions and stabilizing 5′ splicing (U1) regulatory motif patterns may have predisposed P/E elements to regulatory repurposing, and changes in the U1 and polyadenylation signal densities and distributions likely drove the evolutionary activity switches. Our work suggests that regulatory repurposing facilitated regulatory innovation and the origination of new genes and exons during evolution." @default.
- W2892647771 created "2018-10-05" @default.
- W2892647771 creator A5000269294 @default.
- W2892647771 creator A5003538659 @default.
- W2892647771 creator A5050062835 @default.
- W2892647771 creator A5071193102 @default.
- W2892647771 creator A5085413454 @default.
- W2892647771 date "2018-10-04" @default.
- W2892647771 modified "2023-10-14" @default.
- W2892647771 title "Repurposing of promoters and enhancers during mammalian evolution" @default.
- W2892647771 cites W1217705870 @default.
- W2892647771 cites W1501807279 @default.
- W2892647771 cites W1549155795 @default.
- W2892647771 cites W1964963969 @default.
- W2892647771 cites W1969770714 @default.
- W2892647771 cites W1981030303 @default.
- W2892647771 cites W1988760117 @default.
- W2892647771 cites W1991543373 @default.
- W2892647771 cites W1993502678 @default.
- W2892647771 cites W2010291571 @default.
- W2892647771 cites W2011178490 @default.
- W2892647771 cites W2011463791 @default.
- W2892647771 cites W2014677321 @default.
- W2892647771 cites W2014787267 @default.
- W2892647771 cites W2015845481 @default.
- W2892647771 cites W2021678907 @default.
- W2892647771 cites W2032812076 @default.
- W2892647771 cites W2036619779 @default.
- W2892647771 cites W2042930277 @default.
- W2892647771 cites W2068919087 @default.
- W2892647771 cites W2076154138 @default.
- W2892647771 cites W2083073732 @default.
- W2892647771 cites W2083245183 @default.
- W2892647771 cites W2089430148 @default.
- W2892647771 cites W2091533196 @default.
- W2892647771 cites W2092390808 @default.
- W2892647771 cites W2095903180 @default.
- W2892647771 cites W2096465161 @default.
- W2892647771 cites W2098952156 @default.
- W2892647771 cites W2102619694 @default.
- W2892647771 cites W2103441770 @default.
- W2892647771 cites W2104005232 @default.
- W2892647771 cites W2114443206 @default.
- W2892647771 cites W2115948084 @default.
- W2892647771 cites W2118916005 @default.
- W2892647771 cites W2123404806 @default.
- W2892647771 cites W2123564569 @default.
- W2892647771 cites W2124343649 @default.
- W2892647771 cites W2133484520 @default.
- W2892647771 cites W2133727333 @default.
- W2892647771 cites W2136145671 @default.
- W2892647771 cites W2141458291 @default.
- W2892647771 cites W2144934389 @default.
- W2892647771 cites W2161671616 @default.
- W2892647771 cites W2165064122 @default.
- W2892647771 cites W2167315449 @default.
- W2892647771 cites W2168602111 @default.
- W2892647771 cites W2169456326 @default.
- W2892647771 cites W2263703262 @default.
- W2892647771 cites W2313851754 @default.
- W2892647771 cites W2424483111 @default.
- W2892647771 cites W2461965332 @default.
- W2892647771 cites W2540381357 @default.
- W2892647771 cites W2553600202 @default.
- W2892647771 cites W2606434976 @default.
- W2892647771 cites W2621774891 @default.
- W2892647771 cites W2770178180 @default.
- W2892647771 cites W2770429904 @default.
- W2892647771 cites W2789624807 @default.
- W2892647771 cites W2950101853 @default.
- W2892647771 cites W2950817352 @default.
- W2892647771 doi "https://doi.org/10.1038/s41467-018-06544-z" @default.
- W2892647771 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6172195" @default.
- W2892647771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30287902" @default.
- W2892647771 hasPublicationYear "2018" @default.
- W2892647771 type Work @default.
- W2892647771 sameAs 2892647771 @default.
- W2892647771 citedByCount "51" @default.
- W2892647771 countsByYear W28926477712018 @default.
- W2892647771 countsByYear W28926477712019 @default.
- W2892647771 countsByYear W28926477712020 @default.
- W2892647771 countsByYear W28926477712021 @default.
- W2892647771 countsByYear W28926477712022 @default.
- W2892647771 countsByYear W28926477712023 @default.
- W2892647771 crossrefType "journal-article" @default.
- W2892647771 hasAuthorship W2892647771A5000269294 @default.
- W2892647771 hasAuthorship W2892647771A5003538659 @default.
- W2892647771 hasAuthorship W2892647771A5050062835 @default.
- W2892647771 hasAuthorship W2892647771A5071193102 @default.
- W2892647771 hasAuthorship W2892647771A5085413454 @default.
- W2892647771 hasBestOaLocation W28926477711 @default.
- W2892647771 hasConcept C101762097 @default.
- W2892647771 hasConcept C104317684 @default.
- W2892647771 hasConcept C111936080 @default.
- W2892647771 hasConcept C117717151 @default.
- W2892647771 hasConcept C142575336 @default.
- W2892647771 hasConcept C150194340 @default.
- W2892647771 hasConcept C165864922 @default.
- W2892647771 hasConcept C190727270 @default.
- W2892647771 hasConcept C194583182 @default.