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• W2892658217 endingPage "e0204703" @default.
• W2892658217 startingPage "e0204703" @default.
• W2892658217 abstract "Commensal and pathogenic bacteria have evolved efficient enzymatic pathways to feed on host carbohydrates, including protein-linked glycans. Most proteins of the human innate and adaptive immune system are glycoproteins where the glycan is critical for structural and functional integrity. Besides enabling nutrition, the degradation of host N-glycans serves as a means for bacteria to modulate the host's immune system by for instance removing N-glycans on immunoglobulin G. The commensal bacterium Cutibacterium acnes is a gram-positive natural bacterial species of the human skin microbiota. Under certain circumstances, C. acnes can cause pathogenic conditions, acne vulgaris, which typically affects 80% of adolescents, and can become critical for immunosuppressed transplant patients. Others have shown that C. acnes can degrade certain host O-glycans, however, no degradation pathway for host N-glycans has been proposed. To investigate this, we scanned the C. acnes genome and were able to identify a set of gene candidates consistent with a cytoplasmic N-glycan-degradation pathway of the canonical eukaryotic N-glycan core. We also found additional gene sequences containing secretion signals that are possible candidates for initial trimming on the extracellular side. Furthermore, one of the identified gene products of the cytoplasmic pathway, AEE72695, was produced and characterized, and found to be a functional, dimeric exo-β-1,4-mannosidase with activity on the β-1,4 glycosidic bond between the second N-acetylglucosamine and the first mannose residue in the canonical eukaryotic N-glycan core. These findings corroborate our model of the cytoplasmic part of a C. acnes N-glycan degradation pathway." @default.
• W2892658217 created "2018-10-05" @default.
• W2892658217 creator A5001612036 @default.
• W2892658217 creator A5008004251 @default.
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• W2892658217 creator A5049954619 @default.
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• W2892658217 creator A5072204977 @default.
• W2892658217 date "2018-09-27" @default.
• W2892658217 modified "2023-10-05" @default.
• W2892658217 title "Structural and biochemical characterization of the Cutibacterium acnes exo-β-1,4-mannosidase that targets the N-glycan core of host glycoproteins" @default.
• W2892658217 cites W1516782665 @default.
• W2892658217 cites W1905077449 @default.
• W2892658217 cites W1963778872 @default.
• W2892658217 cites W1967470619 @default.
• W2892658217 cites W1968629537 @default.
• W2892658217 cites W1969968936 @default.
• W2892658217 cites W1972375269 @default.
• W2892658217 cites W1984026274 @default.
• W2892658217 cites W1984212477 @default.
• W2892658217 cites W1994439434 @default.
• W2892658217 cites W2004125187 @default.
• W2892658217 cites W2004798786 @default.
• W2892658217 cites W2007128729 @default.
• W2892658217 cites W2012940693 @default.
• W2892658217 cites W2013177897 @default.
• W2892658217 cites W2018042261 @default.
• W2892658217 cites W2022270574 @default.
• W2892658217 cites W2024254387 @default.
• W2892658217 cites W2028161249 @default.
• W2892658217 cites W2029112298 @default.
• W2892658217 cites W2031003027 @default.
• W2892658217 cites W2035503835 @default.
• W2892658217 cites W2036731706 @default.
• W2892658217 cites W2043049790 @default.
• W2892658217 cites W2047885502 @default.
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• W2892658217 cites W2073651068 @default.
• W2892658217 cites W2076261290 @default.
• W2892658217 cites W2077264333 @default.
• W2892658217 cites W2087402433 @default.
• W2892658217 cites W2091035197 @default.
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• W2892658217 cites W2117499182 @default.
• W2892658217 cites W2122008542 @default.
• W2892658217 cites W2122559203 @default.
• W2892658217 cites W2126168699 @default.
• W2892658217 cites W2129140208 @default.
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• W2892658217 cites W2173944725 @default.
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• W2892658217 doi "https://doi.org/10.1371/journal.pone.0204703" @default.
• W2892658217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6160142" @default.
• W2892658217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30261037" @default.
• W2892658217 hasPublicationYear "2018" @default.
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