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- W2892666419 abstract "Summary Ail, a multifunctional outer membrane protein of Yersinia pestis , confers cell binding, Yop delivery and serum resistance activities. Resistance to complement proteins in serum is critical for the survival of Y. pestis during the septicemic stage of plague infections. Bacteria employ a variety of tactics to evade the complement system, including recruitment of complement regulatory factors, such as factor H, C4b‐binding protein (C4BP) and vitronectin (Vn). Y. pestis Ail interacts with the regulatory factors Vn and C4BP, and Ail homologs from Y. enterocolitica and Y. pseudotuberculosis recruit factor H. Using co‐sedimentation assays, we demonstrate that two surface‐exposed amino acids, F80 and F130, are required for the interaction of Y. pestis Ail with Vn, factor H and C4BP. However, although Ail‐F80A/F130A fails to interact with these complement regulatory proteins, it still confers 10,000‐fold more serum resistance than a Δ ail strain and prevents C9 polymerization, potentially by directly interfering with MAC assembly. Using site‐directed mutagenesis, we further defined this additional mechanism of complement evasion conferred by Ail. Finally, we find that at Y. pestis concentrations reflective of early‐stage septicemic plague, Ail weakly recruits Vn and fails to recruit factor H, suggesting that this alternative mechanism of serum resistance may be essential during plague infection." @default.
- W2892666419 created "2018-10-05" @default.
- W2892666419 creator A5027545880 @default.
- W2892666419 creator A5033437268 @default.
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- W2892666419 date "2018-10-26" @default.
- W2892666419 modified "2023-09-25" @default.
- W2892666419 title "Ail provides multiple mechanisms of serum resistance to<i>Yersinia pestis</i>" @default.
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- W2892666419 doi "https://doi.org/10.1111/mmi.14140" @default.
- W2892666419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6351204" @default.
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