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- W2892667675 abstract "Black walnut (Juglans nigra L.) is one of the most economically valuable hardwood species and a high value tree for edible nut production in the United States. Although consumption of black walnut has been linked to multiple health-promoting effects (e.g., antioxidant, antimicrobial, anti-inflammatory), the bioactive compounds have not been systematically characterized. In addition, the associations between different black walnut cultivars and their health-promoting compounds have not been well established. In this study, the kernels of twenty-two black walnut cultivars selected for nut production by the University of Missouri Center for Agroforestry (Columbia, MO, USA) were evaluated for their antibacterial activities using agar-well diffusion assay. Among the selected cultivars, four black walnut cultivars (i.e., Mystry, Surprise, D.34, and A.36) exhibited antibacterial activity against a Gram-positive bacterium (Staphylococcus aureus), whereas other cultivars showed no effect on the inhibition of this bacterium. The antibacterial compounds showing the strongest activity were isolated with bioassay-guided purification and identified using a metabolomics approach. Six antibacterial bioactive compounds responsible for antimicrobial activity were successfully identified. Glansreginin A, azelaic acid, quercetin, and eriodictyol-7-O-glucoside are novel antibacterial compounds identified in the kernels of black walnuts. The metabolomics approach provides a simple and cost-effective tool for bioactive compound identification." @default.
- W2892667675 created "2018-10-05" @default.
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- W2892667675 date "2018-09-29" @default.
- W2892667675 modified "2023-09-27" @default.
- W2892667675 title "Identifying Antibacterial Compounds in Black Walnuts (Juglans nigra) Using a Metabolomics Approach" @default.
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- W2892667675 doi "https://doi.org/10.3390/metabo8040058" @default.
- W2892667675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6316014" @default.
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- W2892667675 hasPublicationYear "2018" @default.
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